Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/45118

TítuloNano-and micro-based systems for immunotolerance induction in multiple sclerosis
Autor(es)Pires, Liliana R.
Marques, Fernanda
Sousa, João Carlos
Cerqueira, João
Pinto, Inês M.
Palavras-chaveImmunomodulation
Microneedles
Multiple sclerosis
Nanoparticles
Tolerance
Data2-Jul-2016
EditoraTaylor & Francis
RevistaHuman Vaccines and Immunotherapeutics
Resumo(s)It is estimated that more than 2.5 million individuals worldwide have multiple sclerosis (MS). MS is an autoimmune neurodegenerative disease resulting from the destruction of the myelin sheath that enwraps axons driven by an immune cell attack to the central nervous system. Current therapeutic programs for MS focus in immunosuppression and more recently in the use of immunomodulatory molecules. These therapeutic approaches provide significant improvements in the management of the disease, but are frequently associated with an increased susceptibility of opportunistic infection. In this commentary, we highlight the application of nano and micro-technologies as emerging and innovative solutions for MS therapy with the potential to restore immune homeostasis via antigen-specific interactions. Furthermore, we propose and discuss the usage of a minimally invasive approach, namely microneedle patches, as a new therapeutic route. Microneedle patches for the delivery of specific antigens to restore immunotolerance in the context of multiple sclerosis.
Tipoother
URIhttp://hdl.handle.net/1822/45118
DOI10.1080/21645515.2016.1138190
ISSN2164-5515
Versão da editorahttp://www.tandfonline.com
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

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