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TitleTau protein is essential for stress-induced brain pathology
Author(s)Lopes, Sofia
Silva, João Vaz
Pinto, Vítor
Dalla, Christina
Kokras, N.
Bedenk, Benedikt
Mack, Natalie
Czisch, Michael
Almeida, Osborne F. X.
Sousa, Nuno
Sotiropoulos, Ioannis
Memory deficits
Emory deficits
Issue date2016
PublisherNational Academy of Sciences
JournalProceedings of the National Academy of Sciences
CitationLopes, S., Vaz-Silva, J., Pinto, V., Dalla, C., Kokras, N., Bedenk, B., . . . Sotiropoulos, I. (2016). Tau protein is essential for stress-induced brain pathology. [Article]. Proceedings of the National Academy of Sciences of the United States of America, 113(26), E3755-E3763. doi: 10.1073/pnas.1600953113
Abstract(s)Exposure to chronic stress is frequently accompanied by cognitive and affective disorders in association with neurostructural adaptations. Chronic stress was previously shown to trigger Alzheimer's-like neuropathology, which is characterized by Tau hyper-phosphorylation and missorting into dendritic spines followed by memory deficits. Here, we demonstrate that stress-driven hippocampal deficits in wild-type mice are accompanied by synaptic missorting of Tau and enhanced Fyn/GluN2B-driven synaptic signaling. In contrast, mice lacking Tau [Tau knockout (Tau-KO) mice] do not exhibit stress-induced pathological behaviors and atrophy of hippocampal dendrites or deficits of hippocampal connectivity. These findings implicate Tau as an essential mediator of the adverse effects of stress on brain structure and function.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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