Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/44905
Título: | Tau protein is essential for stress-induced brain pathology |
Autor(es): | Lopes, Sofia Silva, João Vaz Pinto, Vítor Dalla, Christina Kokras, N. Bedenk, Benedikt Mack, Natalie Czisch, Michael Almeida, Osborne F. X. Sousa, Nuno Sotiropoulos, Ioannis |
Palavras-chave: | Tau Stress Hippocampus Depression Memory deficits Emory deficits |
Data: | 2016 |
Editora: | National Academy of Sciences |
Revista: | Proceedings of the National Academy of Sciences |
Citação: | Lopes, S., Vaz-Silva, J., Pinto, V., Dalla, C., Kokras, N., Bedenk, B., . . . Sotiropoulos, I. (2016). Tau protein is essential for stress-induced brain pathology. [Article]. Proceedings of the National Academy of Sciences of the United States of America, 113(26), E3755-E3763. doi: 10.1073/pnas.1600953113 |
Resumo(s): | Exposure to chronic stress is frequently accompanied by cognitive and affective disorders in association with neurostructural adaptations. Chronic stress was previously shown to trigger Alzheimer's-like neuropathology, which is characterized by Tau hyper-phosphorylation and missorting into dendritic spines followed by memory deficits. Here, we demonstrate that stress-driven hippocampal deficits in wild-type mice are accompanied by synaptic missorting of Tau and enhanced Fyn/GluN2B-driven synaptic signaling. In contrast, mice lacking Tau [Tau knockout (Tau-KO) mice] do not exhibit stress-induced pathological behaviors and atrophy of hippocampal dendrites or deficits of hippocampal connectivity. These findings implicate Tau as an essential mediator of the adverse effects of stress on brain structure and function. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/44905 |
DOI: | 10.1073/pnas.1600953113 |
ISSN: | 0027-8424 |
Versão da editora: | https://www.pnas.org/doi/full/10.1073/pnas.1600953113 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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lopes_et-al-pnas-2016.pdf | 1,73 MB | Adobe PDF | Ver/Abrir |