Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/44896

TitleInterleukin-27 early impacts Leishmania infantum infection in mice and correlates with active visceral disease in humans
Author(s)Pérez-Cabezas, Begoña
Cecílio, Pedro
Robalo, Ana Luísa
Silvestre, Ricardo Jorge Leal
Carrillo, Eugenia
Moreno, Javier
Martín, Juan V. San
Vasconcellos, Rita
Silva, Anabela Cordeiro da
KeywordsIL-27
Leishmania infantum
Human
Mouse models
Immune regulation
Issue dateNov-2016
PublisherFrontiers Media
JournalFrontiers in Immunology
CitationPérez-Cabezas, B., Cecílio, P., Robalo, A. L., Silvestre, R., Carrillo, et. al.(2016). interleukin-27 early impacts Leishmania infantum infection in Mice and correlates with active Visceral Disease in humans. Frontiers in Immunology, 7
Abstract(s)The complexity of Leishmania host interactions, one of the main leishmaniasis issues, is yet to be fully understood. We detected elevated IL-27 plasma levels in European patients with active visceral disease caused by Leishmania infantum, which returned to basal levels after successful treatment, suggesting this cytokine as a probable infection mediator. We further addressed this hypothesis recurring to two classical susceptible visceral leishmaniasis mouse models. BALB/c, but not C57BU6 mice, showed increased IL-27 systemic levels after infection, which was associated with an upregulation of IL-27p28 expression by dendritic cells and higher parasite burdens. Neutralization of IL-27 in acutely infected BALB/c led to decreased parasite burdens and a transient increase in IFN-gamma(+) splenic T cells, while administration of IL-27 to C57BU6 promoted a local anti-inflammatory cytokine response at the site of infection and increased parasite loads. Overall, we show that, as in humans, BALB/c IL-27 systemic levels are infection dependently upregulated and may favor parasite installation by controlling inflammation.
TypeArticle
URIhttp://hdl.handle.net/1822/44896
DOI10.3389/fimmu.2016.00478
ISSN1664-3224
Publisher versionhttp://journal.frontiersin.org/article/10.3389/fimmu.2016.00478/full
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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