Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/44853

TítuloInsights on the pathophysiology of Alzheimer's disease: the crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system
Autor(es)Mesquita, Sandro Gabriel Ferreira Dá
Ferreira, Ana Catarina
Sousa, João Carlos
Neves, Margarida Correia
Sousa, Nuno
Marques, Fernanda
Palavras-chaveAlzheimer's disease
Aging
Amyloid beta
Cognition
Blood-brain barrier
Choroid plexus
Cerebrospinal fluid
Glial cells
Neurons
Cytokines
Neuroinflammation
Immune system
DataSet-2016
EditoraElsevier
RevistaNeuroscience and Biobehavioral Reviews
CitaçãoDá Mesquita, S., Ferreira, A. C., Sousa, J. C., Correia-Neves, M., Sousa, N., & Marques, F. (2016). Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system. Neuroscience & Biobehavioral Reviews, 68, 547-562. doi: 10.1016/j.neubiorev.2016.06.014
Resumo(s)Alzheimer's disease (AD) is the most common form of dementia, whose prevalence is growing along with the increased life expectancy. Although the accumulation and deposition of amyloid beta (Aß) peptides in the brain is viewed as one of the pathological hallmarks of AD and underlies, at least in part, brain cell dysfunction and behavior alterations, the etiology of this neurodegenerative disease is still poorly understood. Noticeably, increased amyloid load is accompanied by marked inflammatory alterations, both at the level of the brain parenchyma and at the barriers of the brain. However, it is debatable whether the neuroinflammation observed in aging and in AD, together with alterations in the peripheral immune system, are responsible for increased amyloidogenesis, decreased clearance of Aß out of the brain and/or the marked deficits in memory and cognition manifested by AD patients. Herein, we scrutinize some important traits of the pathophysiology of aging and AD, focusing on the interplay between the amyloidogenic pathway, neuroinflammation and the peripheral immune system.
Tipoarticle
URIhttp://hdl.handle.net/1822/44853
DOI10.1016/j.neubiorev.2016.06.014
ISSN0149-7634
Versão da editorahttp://www.sciencedirect.com/science/article/pii/S0149763416300094
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

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