Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/44742

TitleMAHMI database: a comprehensive MetaHit-based resource for the study of the mechanism of action of the human microbiota
Author(s)Blanco-Míguez, Aitor
Gutiérrez-Jácome, Alberto
Fdez-Riverola, Florentino
Lourenço, Anália
Sánchez, Borja
Issue date2017
PublisherOup
JournalDatabase - the Journal of Biological Databases and Curation
CitationBlanco-Míguez, Aitor; Gutiérrez-Jácome, Alberto; Fdez-Riverola, Florentino; Lourenço, Anália; Sánchez, Borja, MAHMI database: a comprehensive MetaHit-based resource for the study of the mechanism of action of the human microbiota. Database - The Journal of Biological Databases and Curation, 2017(1), baw157, 2017
Abstract(s)The Mechanism of Action of the Human Microbiome (MAHMI) database is a unique resource that provides comprehensive information about the sequence of potential immunomodulatory and antiproliferative peptides encrypted in the proteins produced by the human gut microbiota. Currently, MAHMI database contains over 300 hundred million peptide entries, with detailed information about peptide sequence, sources and potential bioactivity. The reference peptide data section is curated manually by domain experts. The in silico peptide data section is populated automatically through the systematic processing of publicly available exoproteomes of the human microbiome. Bioactivity prediction is based on the global alignment of the automatically processed peptides with experimentally validated immunomodulatory and antiproliferative peptides, in the reference section. MAHMI provides researchers with a comparative tool for inspecting the potential immunomodulatory or antiproliferative bioactivity of new amino acidic sequences and identifying promising peptides to be further investigated. Moreover, researchers are welcome to submit new experimental evidence on peptide bioactivity, namely, empiric and structural data, as a proactive, expert means to keep the database updated and improve the implemented bioactivity prediction method. Bioactive peptides identified by MAHMI have a huge biotechnological potential, including the manipulation of aberrant immune responses and the design of new functional ingredients/foods based on the genetic sequences of the human microbiome. Hopefully, the resources provided by MAHMI will be useful to those researching gastrointestinal disorders of autoimmune and inflammatory nature, such as Inflammatory Bowel Diseases. MAHMI database is routinely updated and is available free of charge.
TypeArticle
URIhttp://hdl.handle.net/1822/44742
DOI10.1093/database/baw157
ISSN1758-0463
e-ISSN1758-0463
Publisher versionhttp://database.oxfordjournals.org/
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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