Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/44326

TítuloEvaluation of canine adipose-derived stem cells in a healthy mice subcutaneous model
AutorRequicha, J. F.
Carvalho, P. P.
Pires, M. A.
Dias, M. I.
Reis, R. L.
Gomes, M. E.
Viegas, C. A. A.
Palavras-chaveCanine adipose-derived stem cells
Mice subcutaneous model
Dog
Xenotransplantation;
Host response
Mice model
DataDez-2016
CitaçãoRequicha J. F., Carvalho P. P., Pires M. A., Dias M. I., Reis R. L., Gomes M. E., Viegas C. A. A. Evaluation of Canine Adipose-derived Stem Cells in a Healthy Mice Subcutaneous Model, Journal of Stem Cell Research & Therapy, Vol. 6, Issue 9, doi:10.4172/2157-7633.1000358, 2016
ResumoCanine adipose-derived stem cells (cASCs) have great interest for cell-based therapies in Veterinary Medicine. As the behaviour of these cells in non-autologous recipients is not deeply characterized, it is mandatory to study them in new animal models previously to canine specie. In this work, cASCs were injected subcutaneously in mice and these cells were detected by immunohistochemistry using vimentin, CD44 and keratin. The local response evaluated by histology did not reveal signals of significant inflammatory reaction neither in the lymph nodes or other organs. This study showed the implantation of cASCs induced a scarce inflammatory response. Hsd:CD1 (ICR) mouse can be proposed as an animal model to study the in vivo behavior of the cASCs and to validate new cASCs-based approaches avoiding or reducing the use of dogs in research.
Tipoarticle
URIhttp://hdl.handle.net/1822/44326
DOI10.4172/2157-7633.1000358
ISSN2157-7633
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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