Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/44153

TitleBuilding the basis for patient-specific meniscal scaffolds: from human knee MRI to fabrication of 3D printed scaffolds
Author(s)Cengiz, I. F.
Pitikakis, M.
Cesario, L.
Parascandolo, P.
Vosilla, L.
Viano, G.
Oliveira, J. M.
Reis, R. L.
Keywords3D model reconstruction
3D printing
3D scaffold fabrication
meniscus
MRI segmentation
Patient-specific tissue engineering
Reverse Engineering
Issue dateJun-2016
PublisherElsevier
JournalBioprinting
CitationCengiz I. F., Pitikakis M., Cesario L., Parascandolo P., Vosilla L., Viano G., Oliveira J. M., Reis R. L. Building the Basis for Patient-Specific Meniscal Scaffolds: From Human Knee MRI to Fabrication of 3D Printed Scaffolds, Bioprinting, Vol. 1–2, Issue March–June 2016, pp. 1-10, doi:10.1016/j.bprint.2016.05.001, 2016
Abstract(s)The current strategies for the transplantation of meniscus should be strengthened to tackle the faced limitations of current methods in the clinics. One of the limitations is that current implants are not patient-specific. There is, therefore, a pressing need in the clinics to develop patient-specific implants. The aim of this study was to demonstrate a semi-automatic way of segmenting meniscus tissues from patientsâ volumetric knee magnetic resonance imaging (MRI) datasets in order to obtain patient-specific 3D models for 3D printing of patient-specific constructs. High-quality MRI volumetric images were acquired from five healthy male human subjects. The advanced segmentation software, RheumaSCORE, was used for semi-automatic MRI image segmentation of the meniscus tissues. Our methodology allows a full 3D segmentation of the menisci with only minimal interaction on 2D slices. The obtained 3D models were used for the fabrication of tissue engineering scaffolds from polycaprolactone with different internal architectures. The fabricated scaffolds were characterized by micro-computed tomography (µ-CT), scanning electron microscopy (SEM), and mechanical testing. This study demonstrated the 3D fabrication of patient-specific scaffolds with a 3D printer using the reconstructed 3D models obtained by an advanced segmentation method of menisci from knee MRI. This is a step towards a personalized tissue engineering therapy model for the knee meniscus.
TypeArticle
URIhttp://hdl.handle.net/1822/44153
DOI10.1016/j.bprint.2016.05.001
ISSN2405-8866
Publisher versionwww.elsevier.com/locate/bprint
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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