Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/44062

TitleSynthesis and photophysical studies of new benzo[a]phenoxazinium chlorides as potential antifungal agents
Author(s)Leitão, Maria Inês P. S.
Raju, B. Rama
Naik, Sarala
Coutinho, Paulo J. G.
Sousa, Maria João
Gonçalves, M. Sameiro T.
KeywordsBenzo[a]phenoxazinium chloride
Antimicrobial drugs
Saccharomyces cerevisiae
Nile Blue derivatives
NIR probes
Benzo[a]phenoxazinium chlorides
Issue date2016
PublisherElsevier
JournalTetrahedron Letters
CitationM. I. P. S. Leitão, B. R. Raju, S. Naik, P. J. G. Coutinho, M. J. Sousa, M. S. T. Gonçalves, “Synthesis and photophysical studies of new benzo[a]phenoxazinium chlorides as potential antifungal agents”, Tetrahedron Letters, 2016, 57, 3936-3941.
Abstract(s)A set of four new benzo[a]phenoxazinium chlorides possessing ethyl, propyl, decyl and tetradecyl groups at the 9-amino function of the heterocycle along with a propyl group at the 5-amino position was efficiently synthesised. These compounds displayed fluorescence with maximum emission wavelengths of 673 and 685 nm, in anhydrous ethanol and water. All the benzo[a]phenoxazines were evaluated against the yeast Saccharomyces cerevisiae in a broth microdilution assay. It was found that their antifungal activity depended on the variation in the lengths of the aliphatic chains. The highest MIC activity of 1.56 µM was obtained for compound 7 comprising a di-alkylated propyl substituent at 9-amino position and a propyl chain at the 5-amino position of the heterocycle core.
TypeArticle
URIhttp://hdl.handle.net/1822/44062
DOI10.1016/j.tetlet.2016.07.065
ISSN0040-4039
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S004040391630911X
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CDQuim - Artigos (Papers)

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