Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/43884

TitleOxygenated monoterpenes-rich volatile oils as potential antifungal agents for dermatophytes
Author(s)Dias, Nicolina
Dias, M. C.
Cavaleiro, C.
Sousa, M. C.
Lima, Nelson
Machado, M.
KeywordsAntifungals
dermatophytes
pathogenic fungi
skin infections
Issue date2017
PublisherTaylor & Francis
JournalNatural Product Research
CitationDias, Nicolina; Dias, M. C.; Cavaleiro, C.; Sousa, M. C.; Lima, Nelson; Machado, M., Oxygenated monoterpenes-rich volatile oils as potential antifungal agents for dermatophytes. Natural Product Research, 31(4), 460-464, 2017
Abstract(s)Essential oils (EOs) extracted from Lavandula luisieri and Cymbopogon citratus were tested for their antifungal activity against ten clinical isolates of dermatophytes isolated from cases of tinea pedis. Inhibition of conidial germination and antifungal drug/EO combination assay were tested on two ATCC reference strains of Trichophyton rubrum and Trichophyton mentagrophytes. EOs were characterised by high amount of oxygenated monoterpenes in their composition. Strong antifungal activity was observed for the majority of clinical strains, and fungicidal activity was demonstrated. Positive interaction between L. luisieri EO combined with terbinafine was observed against terbinafine-resistant strain (Tr ATCC MYA-4438). Significative reduction of the germination was observed above 100 g mL1. Both oils were safe to macrophage mammalian cells at tested concentration. This study describes the antifungal activity of L. luisieri and C. citratus EOs against dermatophytes, which could be useful in designing new formulations for topical treatments.
TypeArticle
URIhttp://hdl.handle.net/1822/43884
DOI10.1080/14786419.2016.1195379
ISSN1478-6419
e-ISSN1478-6427
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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