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TitleMagnetically controlled drug release system through magneto-mechanical actuation
Author(s)Barbosa, J.
Correia, D. M.
Gonçalves, R.
Ribeiro, Clarisse Marta Oliveira
Botelho, Gabriela
Martins, P.
Lanceros-Méndez, S.
KeywordsDrug releases
Magnetostrictive materials
Biomedical materials
Issue date2016
PublisherWiley-VCH Verlag
JournalAdvanced Healthcare Materials
CitationAdvanced Healthcare Materials.Volume 5, Issue 23 December 7, 2016 Pages
Abstract(s)A drug release system is developed capable to modulate e drug release kinetics by the application of a magnetic field. Thus, this work reports on the production, characterization and release kinetics of a poly(L-lactic acid) (PLLA) microporous membrane containing a zeolite (Faujasite) and a magnetic stimuli-sensitive component, magnetostrictive Terfenol-D (TD), for the release of ibuprofen (IBU) as drug model. For membranes containing IBU-loaded zeolites and TD without an applied AC magnetic field, the release kinetics is characterized by a first order release. On the other hand, the application of an AC magnetic field modifies the release profile of the membrane, leading to an increase of the release rate by more than 30%, the magnetically driven release being characterized by a super case-II within the Korsmeyer-Peppas model, indicating a release mainly driven by a swelling or erosion mechanism, induced by the magnetostrictive particles under the applied magnetic field. Further, it is stated that increasing TD content above 10% w/w leads to a decrease in the IBU release, whereas increasing the HAC field increases the release performance of the developed system.
AccessRestricted access (UMinho)
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
CDF - FCD - Artigos/Papers (with refereeing)

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