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TitleA comparative approach of tumor associated inflammation in mammary cancer between humans and dogs
Author(s)Carvalho, Maria
Carvalho, Ricardo Silva
Pires, Isabel M. S.
Prada, Justina
Bianchini, Rodolfo
Jnsen-Jarolim, Erika
Queiroga, Felisbina Luisa
KeywordsCanine mammary tumors
Human breast cancer
Mammary carcinogenesis
Tumor-associated inflammation
Tumor hallmark capabilities
Issue date2016
PublisherHindawi Publishing Corporation
JournalBiomed Research International
CitationCarvalho, Maria; Silva-Carvalho, Ricardo; Pires, Isabel M. S.; Prada, Justina; Bianchini, Rodolfo; Jnsen-Jarolim, Erika; Queiroga, Felisbina Luisa, A comparative approach of tumor associated inflammation in mammary cancer between humans and dogs. BioMed Research International, 2016(4917387), 1-12, 2016
Abstract(s)Infiltrating cells of the immune system are widely accepted to be generic constituents of tumor microenvironment. It has been well established that the development of mammary cancer, both in humans and dogs, is associated with alterations in numbers and functions of immune cells at the sites of tumor progression. These tumor infiltrating immune cells seems to exhibit exclusive phenotypic and functional characteristics and mammary cancer cells can take advantage of signaling molecules released by them. Cancer related inflammation has an important role in mammary carcinogenesis, contributing to the acquisition of core hallmark capabilities that allow cancer cells to survive, proliferate, and disseminate. Indeed, recent studies in human breast cancer and in canine mammary tumors have identified a growing list of signaling molecules released by inflammatory cells that serve as effectors of their tumor-promoting actions. These include the COX-2, the tumor growth factor EGF, the angiogenic growth factor VEGF, other proangiogenic factors and a large variety of chemokines and cytokines that amplify the inflammatory state. This review describes the intertwined signaling pathways shared by Tlymphocytic/macrophage infiltrates and important tissue biomarkers in both human and dog mammary carcinogenesis.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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