Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/43830

TitleAntibacterial bioadhesive layer-by-layer coatings for orthopedic applications
Author(s)Carvalho, A. L.
Vale, A. C.
Sousa, M. P.
Barbosa, A. M.
Torrado, Egídio
Mano, J. F.
Alves, N. M.
KeywordsAdsorption
Bioactive glass Nanoparticles
Chitosan
Cross-linking
Fabrication
Hyaluronic-acid
Mechanics
Mussel-adhesive
Silver nanoparticles
Surface
Issue dateJul-2016
PublisherRoyal Society of Chemistry
JournalJournal of Materials Chemistry B
CitationCarvalho A. L., Vale A. C., Sousa M. P., Barbosa A. M., Torrado E., Mano J. F., Alves N. M. Antibacterial bioadhesive layer-by-layer coatings for orthopedic applications, Journal Of Materials Chemistry B, Vol. 4, pp. 5385-5393, doi:10.1039/C6TB00841K, 2016
Abstract(s)In this study, thin LbL films were produced by combining the adhesive properties of the hyaluronic acidâ dopamine conjugate with the bioactivity and bactericidal properties of silver doped bioactive glass nanoparticles. The build-up of these films was investigated by quartz crystal microbalance with dissipation monitoring. LbL coatings were then constructed on a glass substrate for further characterization. We found that these antimicrobial bioinspired films display enhanced adhesive strength. In vitro bioactivity tests were performed by immersing them in simulated body fluid solution for 14 days where the constructed films promoted the formation of a bone-like apatite layer. From microbiological assays, it was found that coatings containing silver doped nanoparticles exhibited a remarkable antibacterial effect against Staphylococcus aureus and Escherichia coli cultures. Finally, in vitro cellular behavior tests showed enhanced cell adhesion, proliferation and viability for these antibacterial bioadhesive films. Therefore, the constructed thin films showed promising properties and evidenced great potential to be used as coatings for orthopedic implants.
TypeArticle
URIhttp://hdl.handle.net/1822/43830
DOI10.1039/C6TB00841K
ISSN2050-750X
Publisher versionhttp://dx.doi.org/10.1039/C6TB00841K
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals
ICVS - Artigos em Revistas Internacionais com Referee

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