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TitleManagement of knee osteoarthritis: current status and future trends
Author(s)Ondrésik, M.
Maia, F. Raquel
Morais, Alain José Silva
Gertrudes, Ana
Bacelar, Ana Helena Dias
Correia, Cristina
Gonçalves, Cristiana R.
Radhouani, Hajer
Sousa, R. A.
Oliveira, J. M.
Reis, R. L.
KeywordsArticular cartilage
Gene therapy
Tissue engineering
Issue date2017
PublisherJohn Wiley and Sons
JournalBiotechnology and Bioengineering
CitationOndrésik M., Maia F. R., da Silva Morais A., Gertrudes A., Bacelar A. H., Correia C., Gonçalves C., Radhouani H., Sousa R.A., Oliveira J. M., Reis R. L. Management of knee osteoarthritis. Current status and future trends., Biotechnology and Bioengineering, pp. 1-23, doi:10.1002/bit.26182, 2016
Abstract(s)Osteoarthritis (OA) affects a large number of the population, and its incidence is showing a growing trend with the increasing life span. OA is the most prevalent joint condition worldwide, and currently, there is no functional cure for it. This review seeks to briefly overview the management of knee OA concerning standardized pharmaceutical and clinical approaches, as well as the new biotechnological horizons of OA treatment. The potential of biomaterials and state of the art of advanced therapeutic approaches, such as cell and gene therapy focused primarily on cartilage regeneration are the main subjects of this review. Biotechnol. Bioeng. 2016;9999: 1-23. © 2016 Wiley Periodicals, Inc.
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AccessRestricted access (Author)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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