Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/43700

TitleDevelopment of an injectable calcium Phosphate/Hyaluronic acid microparticles system for platelet lysate sustained delivery aiming bone regeneration
Author(s)Babo, Pedro Miguel Sousa
Santo, Vítor Sérgio Soares Espírito
Gomes, Manuela E.
Reis, R. L.
KeywordsBone regeneration
Drug delivery
Growth factors
Injectable CaP cements
Platelet lysate
Issue dateAug-2016
PublisherWiley-VCH Verlag
JournalMacromolecular Bioscience
CitationBabo P. S., Santo V. E., Gomes M. E., Reis R. L. Development of an Injectable Calcium Phosphate/Hyaluronic Acid Microparticles System for Platelet Lysate Sustained Delivery Aiming Bone Regeneration, Macromolecular Bioscience, doi:10.1002/mabi.201600141, 2016
Abstract(s)Despite the biocompatibility and osteoinductive properties of calcium phosphate (CaP) cements their low biodegradability hampers full bone regeneration. Herein the incorporation of CaP cement with hyaluronic acid (HAc) microparticles loaded with platelet lysate (PL) to improve the degradability and biological performance of the cements is proposed. Cement formulations incorporating increasing weight ratios of either empty HAc microparticles or microparticles loaded with PL (10 and 20 wt%) are developed as well as cements directly incorporating PL. The direct incorporation of PL improves the mechanical properties of the plain cement, reaching values similar to native bone. Morphological analysis shows homogeneous particle distribution and high interconnectivity between the HAc microparticles. The cements incorporating PL (with or without the HAc microparticles) present a sustained release of PL proteins for up to 8 d. The sustained release of PL modulates the expression of osteogenic markers in seeded human adipose tissue derived stem cells, thus suggesting the stimulatory role of this hybrid system toward osteogenic commitment and bone regeneration applications.
TypeArticle
URIhttp://hdl.handle.net/1822/43700
DOI10.1002/mabi.201600141
ISSN1616-5195
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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