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|Title:||Molecularly imprinted intelligent scaffolds for tissue engineering applications|
|Author(s):||Neves, M. I.|
Wechsler, M. E.
Gomes, Manuela E.
Reis, R. L.
Granja, P. L.
Peppas, N. A.
|Publisher:||Mary Ann Liebert|
|Journal:||Tissue Engineering. Part A|
|Citation:||Neves M. I., Wechsler M. E., Gomes M. E., Reis R. L., Granja P. L., Peppas N. A. Molecularly imprinted intelligent scaffolds for tissue engineering applications, Tissue Engineering: Part B, doi: 10.1089/ten.teb.2016.0202, 2017.|
|Abstract(s):||The development of molecularly imprinted polymers (MIPs) using biocompatible production methods enables theÂ possibility to further exploit this technology for biomedical applications. Tissue engineering (TE) approachesÂ use the knowledge of the wound healing process to design scaffolds capable of modulating cell behavior andÂ promote tissue regeneration. Biomacromolecules bear great interest for TE, together with the established recognitionÂ of the extracellular matrix, as an important source of signals to cells, both promoting cellâ cell and cellâ matrix interactions during the healing process. This review focuses on exploring the potential of protein molecularÂ imprinting to create bioactive scaffolds with molecular recognition for TE applications based on the most recentÂ approaches in the field of molecular imprinting of macromolecules. Considerations regarding essential componentsÂ of molecular imprinting technology will be addressed for TE purposes. Molecular imprinting of biocompatibleÂ hydrogels, namely based on natural polymers, is also reviewed here. Hydrogel scaffolds with molecularÂ memory show great promise for regenerative therapies. The first molecular imprinting studies analyzing cell adhesionÂ report promising results with potential applications for cell culture systems, or biomaterials for implantationÂ with the capability for cell recruitment by selectively adsorbing desired molecules.|
|Appears in Collections:||3B’s - Artigos em revistas/Papers in scientific journals|
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