Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/43407
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Abreu, Ana S. | por |
dc.contributor.author | Hermenegildo, Bruno Filipe Costa | por |
dc.contributor.author | Ferreira, Paula M. T. | por |
dc.contributor.author | Queiroz, Maria João R. P. | por |
dc.contributor.author | Castanheira, Elisabete M. S. | por |
dc.date.accessioned | 2016-12-13T11:53:18Z | - |
dc.date.issued | 2016-07 | - |
dc.identifier.citation | RSC Adv., 2016,6, 72141-72148 | por |
dc.identifier.issn | 2046-2069 | por |
dc.identifier.uri | https://hdl.handle.net/1822/43407 | - |
dc.description.abstract | The photophysical properties of two quinolin-2-one and two coumarin derivatives, a 3-amino-4-phenylquinolin-2-one 1, a N-(tert-butyloxycarbonyl)amino-4-phenylcoumarin 2, and the dipeptides 3 and 4 bearing the quinolin-2-one or the coumarin moiety, respectively, synthesized earlier by some of us, were studied in solvents of different polarity. Compounds 1 and 2 show a moderate solvent sensitive emission, quinolinone 1 exhibiting the highest fluorescence quantum yields (between 0.04 and 0.24). The dipeptide derivatives 3 and 4 present reasonable fluorescence quantum yields in several media, including water (between 0.02 and 0.08). Quinolin-2-one (1 and 3) and coumarin (2 and 4) derivatives were incorporated in lipid vesicles of egg lecithin (egg-PC), DPPC, DPPG and mixed DPPC/DPPG (1:1). All compounds are mainly located in the lipid bilayer, feeling the transition between the rigid gel phase and the fluid liquid-crystalline phase. Dynamic light scattering measurements indicated that the liposomes with the encapsulated compounds are generally monodisperse and with hydrodynamic diameters lower than 160 nm, suitable for biomedical applications. | por |
dc.description.sponsorship | Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2013 (CF-UM-UP) and PEst-C/QUI/UI0686/2013 (FCOMP-01-0124-FEDER-022716) (CQ-UM). FCT, POPH-QREN and FSE are acknowledged for the post-Doc. grant of A.S.A. (SFRH/BPD/24548/2005). | por |
dc.language.iso | eng | por |
dc.publisher | Royal Society of Chemistry | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147414/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/COMPETE/132953/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F24548%2F2005/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | Fluorescence | por |
dc.subject | Quinolinones | por |
dc.subject | Coumarins | por |
dc.subject | Liposomes | por |
dc.subject | Dipeptides | por |
dc.title | Interaction of fluorescent quinolin-2-one and coumarin derivatives including dipeptides with lipid bilayers | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra14376h#!divAbstract | por |
sdum.publicationstatus | info:eu-repo/semantics/publishedVersion | por |
oaire.citationStartPage | 72141 | por |
oaire.citationEndPage | 72148 | por |
oaire.citationIssue | 76 | por |
oaire.citationTitle | RSC Advances | por |
oaire.citationVolume | 6 | por |
dc.identifier.doi | 10.1039/C6RA14376H | por |
dc.subject.fos | Ciências Naturais::Ciências Físicas | por |
dc.subject.fos | Ciências Naturais::Ciências Químicas | por |
dc.subject.fos | Ciências Naturais::Outras Ciências Naturais | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | RSC Advances | por |
Aparece nas coleções: | CDF - FAMO - Artigos/Papers (with refereeing) CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Interaction of 2-quinolinones and coumarins_Advance Article.pdf Acesso restrito! | 1,17 MB | Adobe PDF | Ver/Abrir |