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TitleMC3T3-E1 cell response to Ti1xAgx and Ag-TiNx electrodes deposited on piezoelectric poly(vinylidene fluoride) substrates for sensor spplications
Author(s)Marques, S.
Rico, P.
Carvalho, Isabel
Ribelles, J. L. Gómez
Fialho, L.
Lanceros-Méndez, S.
Henriques, Mariana
Carvalho, S.
Ag nanoparticles
piezoelectric polymers
MC3T3 osteoblastic cells
Issue date2016
PublisherAmerican Chemical Society
JournalACS Applied Materials and Interfaces
CitationMarques, S.; Rico, P.; Carvalho, Isabel; Ribelles, J. L. Gómez; Fialho, L.; Lanceros-Méndez, S.; Henriques, Mariana; Carvalho, S., MC3T3-E1 cell response to Ti1xAgx and Ag-TiNx electrodes deposited on piezoelectric poly(vinylidene fluoride) substrates for sensor spplications. ACS Applied Materials & Interfaces, 8(6), 4199-4207, 2016
Abstract(s)In the sensors field, titanium based coatings are being used for the acquisition/application of electrical signals from/to piezoelectric materials. In this particular case, sensors are used to detect dynamic mechanical loads at early stages after intervention of problems associated with prostheses implantation. The aim of this work is to select an adequate electrode for sensor applications capable, in an initial stage to avoid bone cell adhesion, but at a long stage, permit osteointegration and osteoinduction. This work reports on the evaluation of osteoblast MC3T3-E1 cells behavior in terms of proliferation, adhesion and long-term differentiation of two different systems used as sensor electrodes: Ti1xAgx and Ag-TiNx deposited by d.c. and pulsed magnetron sputtering at room temperature on poly(vinylidene fluoride) (PVDF). The results indicated an improved effect of Ag-TiNx electrodes compared with Ti1xAgx and TiN, in terms of diminished cell adhesion and proliferation at an initial cell culture stage. Nevertheless, when cell culture time is longer, cells grown onto Ag-TiNx electrodes are capable to proliferate and also differentiate at proper rates, indicating the suitability of this coating for sensor application in prostheses devices. Thus, the Ag-TiNx system was considered the most promising electrode for tissue engineering applications in the design of sensors for prostheses to detect dynamic mechanical loads.
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
CDF - FCD - Artigos/Papers (with refereeing)
CDF - GRF - Artigos/Papers (with refereeing)

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