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|Title:||Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine|
|Author(s):||Martins, Ivone M.|
Reis, R. L.
Azevedo, Helena S.
|Publisher:||American Chemical Society|
|Journal:||ACS Chemical Biology|
|Citation:||Martins, I.; Reis, Rui L.; Azevedo, Helena S., Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine. ACS Chemical Biology, 11(11), 2962-2980, 2016|
|Abstract(s):||The field of regenerative medicine has been gaining momentum steadily over the past few years. The emphasis in regenerative medicine is to use various in-vitro and in-vivo approaches that leverage on the intrinsic healing mechanisms of the body to treat patients with disabling injuries and chronic diseases such as diabetes, osteoarthritis, and degenerative disorders of the cardiovascular and central nervous system. Phage display has been successfully employed to identify peptide ligands for a wide variety of targets, ranging from relatively small molecules (enzymes, cell receptors) to inorganic, organic, and biological (tissues) materials. Over the last two decades, phage display technology has advanced tremendously and has become a powerful tool in the most varied fields of research, including biotechnology, materials science, cell biology, pharmacology, and diagnostics. The growing interest in and success of phage display libraries is largely due its incredible versatility and practical use. This review discusses the potential of phage display technology in biomaterials engineering for applications in regenerative medicine.|
|Description:||The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acschembio.5b00717. Table S1 shows the follow-up analysis on the subsequent applications of peptide sequences listed in Table 1 (PDF).|
|Appears in Collections:||CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series|