Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/43247

TitlePhage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine
Author(s)Martins, Ivone M.
Reis, R. L.
Azevedo, Helena S.
KeywordsRegenerative Medicine
Biomaterials
Phage Display
Issue date23-Sep-2016
PublisherAmerican Chemical Society
JournalACS Chemical Biology
CitationMartins, I.; Reis, Rui L.; Azevedo, Helena S., Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine. ACS Chemical Biology, 11(11), 2962-2980, 2016
Abstract(s)The field of regenerative medicine has been gaining momentum steadily over the past few years. The emphasis in regenerative medicine is to use various in-vitro and in-vivo approaches that leverage on the intrinsic healing mechanisms of the body to treat patients with disabling injuries and chronic diseases such as diabetes, osteoarthritis, and degenerative disorders of the cardiovascular and central nervous system. Phage display has been successfully employed to identify peptide ligands for a wide variety of targets, ranging from relatively small molecules (enzymes, cell receptors) to inorganic, organic, and biological (tissues) materials. Over the last two decades, phage display technology has advanced tremendously and has become a powerful tool in the most varied fields of research, including biotechnology, materials science, cell biology, pharmacology, and diagnostics. The growing interest in and success of phage display libraries is largely due its incredible versatility and practical use. This review discusses the potential of phage display technology in biomaterials engineering for applications in regenerative medicine.
TypeArticle
DescriptionThe Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acschembio.5b00717. Table S1 shows the follow-up analysis on the subsequent applications of peptide sequences listed in Table 1 (PDF).
URIhttp://hdl.handle.net/1822/43247
DOI10.1021/acschembio.5b00717
ISSN1554-8929
e-ISSN1554-8937
Publisher versionhttp://pubs.acs.org/journal/acbcct
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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