Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/42617

Full metadata record
DC FieldValueLanguage
dc.contributor.authorCucchiarini, Magalipor
dc.contributor.authorGirolamo, Laura depor
dc.contributor.authorFilardo, Giuseppepor
dc.contributor.authorOliveira, J. M.por
dc.contributor.authorOrth, Patrickpor
dc.contributor.authorPape, Dietrichpor
dc.contributor.authorReboul, Paulpor
dc.date.accessioned2016-09-15T11:51:34Z-
dc.date.available2016-09-15T11:51:34Z-
dc.date.issued2016-09-
dc.identifier.citationCucchiarini M., de Girolamo L., Filardo G., Oliveira J. M., Orth P., Pape D., Reboul P. Basic science of osteoarthritis, Journal of Experimental Orthopaedics, Vol. 3, Issue 22, pp. 1-18, doi:10.1186/s40634-016-0060-6, 2016-
dc.identifier.issn2197-1153-
dc.identifier.urihttp://hdl.handle.net/1822/42617-
dc.description.abstractOsteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large population worldwide and for which there is no definitive cure. This review provides critical insights into the basic knowledge on OA that may lead to innovative end efficient new therapeutic regimens. While degradation of the articular cartilage is the hallmark of OA, with altered interactions between chondrocytes and compounds of the extracellular matrix, the subchondral bone has been also described as a key component of the disease, involving specific pathomechanisms controlling its initiation and progression. The identification of such events (and thus of possible targets for therapy) has been made possible by the availability of a number of animal models that aim at reproducing the human pathology, in particular large models of high tibial osteotomy (HTO). From a therapeutic point of view, mesenchymal stem cells (MSCs) represent a promising option for the treatment of OA and may be used concomitantly with functional substitutes integrating scaffolds and drugs/growth factors in tissue engineering setups. Altogether, these advances in the fundamental and experimental knowledge on OA may allow for the generation of improved, adapted therapeutic regimens to treat human OA.por
dc.language.isoengpor
dc.publisherSpringerOpenpor
dc.rightsopenAccesspor
dc.subjectAnimal modelspor
dc.subjectArticular cartilagepor
dc.subjectBonepor
dc.subjectInterfacepor
dc.subjectOsteoarthritispor
dc.subjectPathomechanismspor
dc.subjectStem cellspor
dc.subjectTissue engineeringpor
dc.titleBasic science of osteoarthritispor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttps://doi.org/10.1186/s40634-016-0060-6por
dc.commentshttp://www.3bs.uminho.pt/node/18825por
sdum.publicationstatusinfo:eu-repo/semantics/publishedVersionpor
oaire.citationStartPage1por
oaire.citationEndPage18por
oaire.citationIssue22-
oaire.citationTitleJournal of Experimental Orthopaedicspor
dc.date.updated2016-09-15T08:15:09Z-
dc.identifier.doi10.1186/s40634-016-0060-6por
sdum.journalJournal of Experimental Orthopaedicspor
Appears in Collections:3B’s - Publicações em atas de conferências - indexadas no ISI Web of Science

Files in This Item:
File Description SizeFormat 
18825-2016 JEXO ICL paper.pdf2,63 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID