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dc.contributor.authorRibeiro, Viviana Pintopor
dc.contributor.authorAlmeida, Lília Rosa Santos Pintopor
dc.contributor.authorMartins, Ana Regina Ferreirapor
dc.contributor.authorPashkuleva, I.por
dc.contributor.authorMarques, A. P.por
dc.contributor.authorRibeiro, Ana S.por
dc.contributor.authorSilva, Carla J.por
dc.contributor.authorBonifácio, Graçapor
dc.contributor.authorSousa, Rui Pedro Romero Amandipor
dc.contributor.authorOliveira, Ana Leite Almeida Monteiropor
dc.contributor.authorReis, R. L.por
dc.identifier.citationRibeiro V. P., Almeida L., Martins A. R., Pashkuleva I., Marques A. P., Ribeiro A. S., Silva C. J., Bonifácio G., Sousa R. A., Oliveira A. L., Reis R. L. Modulating cell adhesion to polybutylene succinate biotextile constructs for tissue engineering applications, J Tissue Eng Regen Med, doi:10.1002/term.2189, 2017.por
dc.description.abstractTextile-based technologies are powerful routes for the production of three-dimensional porous architectures for tissue engineer- ing applications because of their feasibility and possibility for scaling-up. Herein, the use of knitting technology to produce polybutylene succinate fibre-based porous architectures is described. Furthermore, different treatments have been applied to functionalize the surface of the scaffolds developed: sodium hydroxide etching, ultraviolet radiation exposure in an ozone atmosphere and grafting (acrylic acid, vinyl phosphonic acid and vinyl sulphonic acid) after oxygen plasma activation as a way to tailor cell adhesion. A possible effect of the applied treatments on the bulk properties of the textile scaffolds has been considered and thus tensile tests in dry and hydrated states were also carried out. The microscopy results indicated that the surface morphol- ogy and roughness were affected by the applied treatments. The X-ray photoelectron spectroscopy and contact angle measure- ments showed the incorporation of oxygen-containing groups and higher surface free energy as result of the surface treatments applied. The DNA quantification and scanning electron microscopy analysis revealed that these modifications enhanced cell adhesion and altered cell morphology. Generally, sodium hydroxide treatment altered most significantly the surface properties, which in turn resulted in a high number of cells adherent to these surfaces. Based on the results obtained, the proposed surface treatments are appropriate to modify polybutylene succinate knitting scaffolds, influencing cell adhesion and its potential for use in tissue engineering applications. por
dc.description.sponsorshipPortuguese Foundation for Science and Technology (FCT) under POCTI and/or FEDERprogrammes under the scope of the project TISSUE2TISSUE (PTDC/CTM/105703/ 2008). The FCT distinction attributed to ALO under the Investigator FCT programme (IF/00411/2013)por
dc.publisherJohn Wiley and Sonspor
dc.subjectknitted structurepor
dc.subjectPolybutylene succinatepor
dc.subjectSurface modificationpor
dc.subjectTissue engineeringpor
dc.titleModulating cell adhesion to polybutylene succinate biotextile constructs for tissue engineering applicationspor
oaire.citationTitleJournal of Tissue Engineering and Regenerative Medicinepor
dc.subject.wosScience & Technologypor
sdum.journalJournal of Tissue Engineering and Regenerative Medicinepor
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