Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/42494

TítuloPhoto-cross-linked laminarin-based hydrogels for biomedical applications
Autor(es)Custódio, Catarina Almeida
Reis, R. L.
Mano, J. F.
CitaçãoCustódio C. A., Reis R. L., Mano J. F. Photocrosslinked Laminarin based hydrogels for biomedical applications, Biomacromolecules, Vol. 17, pp. 1602-1609, doi:10.1021/acs.biomac.5b01736, 2016
Resumo(s)Laminarin is a low-molecular-weight (<10 kDa) glucan found in brown algae made up of β(1â 3)-glucan with β(1â 6)-branches. This is one of the most abundant carbon sources in the marine ecosystem. Laminarin has been found to possess various biological interesting properties, such as antioxidant and antimicrobial activities. An attractive feature of laminarin is its inherently low viscosity and high solubility in organic and aqueous solvents that facilitate processing. This makes laminarin an appealing material for the development of new hydrogels that can be easily injected through minimally invasive procedures or used for microfabrication of hydrogels. An approach for synthesizing photo-crosslinkable laminarin hydrogels is presented in this work for the first time. Photo-cross-linkable laminarin was prepared by chemical modification with acrylate groups. The synthesized photo-cross-linkable laminarin material provides the basis for the development of a new injectable system for biomedical purposes that could be used alone or with encapsulated cells or biological molecules. The cross-linking of the methacrylated laminarin is straightforward via photoinitiated polymerization. The possibility to control the methacrylation degree of laminarin and to prepare solutions up to at least 15% w/v permits us to obtain hydrogels with tuned and wide range of stiffness and swelling. Furthermore, the encapsulation of human-adipose-derived stem cells encapsulated in the photo-cross-linked hydrogels demonstrated in vitro biocompatibility.
Versão da editorahttp://pubs.acs.org/doi/abs/10.1021/acs.biomac.5b01736
Arbitragem científicayes
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
18722-CCustodio-Biomacromolecules 2016.pdf5,52 MBAdobe PDFVer/Abrir  Solicitar cópia ao autor!

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu Currículo DeGóis