Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/42490

TítuloDesign and properties of novel substituted borosilicate bioactive glasses and their glass-ceramic derivatives
AutorFernandes, João S.
Gentile, Piergiorgio
Moorehead, Robert
Crawford, Aileen
Miller, Cheryl A.
Pires, Ricardo A.
Hatton, Paul V.
Reis, R. L.
Palavras-chaveBioactive glasses
Borosilicate
Crystallisation
Glass-inomer
DataMai-2016
EditoraAmerican Chemical Society
CitaçãoFernandes J. S., Gentile P., Moorehead R., Miller C., Pires R. A., Hatton P. V., Reis R. L. Design and Properties of Novel Substituted Borosilicate Bioactive Glasses and Their Glass-Ceramic Derivatives, Crystal Growth & Design, doi:10.1021/acs.cgd.6b00231, 2016
ResumoThree novel borosilicate bioactive glasses (BBGs) of general formula of 0.05Na2O·0.35x·0.20B2O3·0.40SiO2 (molar ratio, where x = MgO or CaO or SrO) were prepared and used to investigate the effect of crystallization on their properties including cytotoxicity. The three postmelt compositions were determined using X-ray fluorescence spectroscopy, and crystallization events were studied using differential thermal analysis and X-ray diffraction. This information was used to determine heat treatments to prepare glass-ceramics by controlled crystallization. X-ray diffraction analysis and Fourier transform infrared spectroscopy showed that, after higher heat treatment temperatures (800–900 °C), borosilicate bioactive glass-ceramics (BBGCs) contained mainly borate and silicate crystalline phases. Specifically, BBG-Mg, BBG-Ca, and BBG-Sr glass-ceramics detected the presence of magnesium silicate-Mg2(SiO3)2 and magnesium borate-Mg2B2O5; wollastonite-2M-CaSiO3 and calcium borate-Ca(BO2)2; and strontium silicate-SrSiO3 and strontium borate-Sr2B2O5, respectively. In vitro cytotoxicity tests were performed using the mouse fibroblast cell line (L929). Glass and glass ceramic at concentrations lower than 50 mg/mL did not exhibit any level of cytotoxicity when compared with the control. However, quantitative evaluation indicated that greater cell growth occurred in the presence of materials with crystalline phases. Control of BBGs crystallization may therefore be used to influence the biocompatibility of these glass-ceramic systems.
Tipoarticle
URIhttp://hdl.handle.net/1822/42490
DOI10.1021/acs.cgd.6b00231
ISSN1528-7483
1528-7505
Arbitragem científicayes
AcessorestrictedAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
18771-Fernandes_2016_ASAP.pdf6,17 MBAdobe PDFVer/Abrir  Solicitar cópia ao autor!

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu Currículo DeGóis