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TitleContinuous-flow precipitation as a route to prepare highly controlled nanohydroxyapatite: in vitromineralization and biological evaluation
Author(s)Castro, Filipa Juliana Fernandes
Ribeiro, Viviana Pinto
Ferreira, António
Oliveira, A. L.
Reis, R. L.
Teixeira, J. A.
Rocha, Fernando
Calcium phosphates
Oscillatory flow reactor
Issue dateJul-2016
PublisherIOP Publishing
JournalMaterials Research Express
CitationRibeiro V. P., Castro F., Ferreira A., Oliveira A. L., Reis R. L., Teixeira J. A., Rocha F. Continuous-flow precipitation as a route to prepare highly controlled nanohydroxyapatite: in vitro mineralization and biological evaluation, Materials Research Express, Vol. 3, Issue 7, doi:10.1088/2053-1591/3/7/075404, 2016
Abstract(s)This work reports the biological evaluation of nanosized hydroxyapatite (HAp) previously synthesized by continuous-flow precipitation in a scaled-up meso oscillatory flow reactor (meso-OFR). Physico- chemical characterization of the synthesized HAp suggests high surface reactivity namely because of its high specific surface area and low crystallinity. On the other hand, in vitro biomineralization assays demonstrated the apatite-forming activity of the prepared HAp and their higher surface reactivity when compared to a commercial HAp. Furthermore, human osteoblastic-like (Saos-2) cells culture evidenced that the synthesized HAp stimulated cell proliferation, especially when applied at lower concentrations (30 and 50 μg mlâ 1), although its cellular uptake behavior. Therefore, the prepared HAp shows immense potential as biomedical material, as well as drug and gene delivery vehicle. The results are also very promising regarding further scaling up of the process, as the designed methodology allow for the preparation in a continuous mode of nanosized HAp with controlled physico-chemical properties.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals
CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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