Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/42485

TítuloContinuous-flow precipitation as a route to prepare highly controlled nanohydroxyapatite: in vitromineralization and biological evaluation
AutorCastro, Filipa Juliana Fernandes
Ribeiro, Viviana Pinto
Ferreira, António
Oliveira, A. L.
Reis, R. L.
Teixeira, J. A.
Rocha, Fernando
Palavras-chaveNanohydroxyapatite
Calcium phosphates
Oscillatory flow reactor
Mineralization
SBF
DataJul-2016
EditoraIOP Publishing
CitaçãoRibeiro V. P., Castro F., Ferreira A., Oliveira A. L., Reis R. L., Teixeira J. A., Rocha F. Continuous-flow precipitation as a route to prepare highly controlled nanohydroxyapatite: in vitro mineralization and biological evaluation, Materials Research Express, Vol. 3, Issue 7, doi:10.1088/2053-1591/3/7/075404, 2016
ResumoThis work reports the biological evaluation of nanosized hydroxyapatite (HAp) previously synthesized by continuous-flow precipitation in a scaled-up meso oscillatory flow reactor (meso-OFR). Physico- chemical characterization of the synthesized HAp suggests high surface reactivity namely because of its high specific surface area and low crystallinity. On the other hand, in vitro biomineralization assays demonstrated the apatite-forming activity of the prepared HAp and their higher surface reactivity when compared to a commercial HAp. Furthermore, human osteoblastic-like (Saos-2) cells culture evidenced that the synthesized HAp stimulated cell proliferation, especially when applied at lower concentrations (30 and 50 μg mlâ 1), although its cellular uptake behavior. Therefore, the prepared HAp shows immense potential as biomedical material, as well as drug and gene delivery vehicle. The results are also very promising regarding further scaling up of the process, as the designed methodology allow for the preparation in a continuous mode of nanosized HAp with controlled physico-chemical properties.
Tipoarticle
URIhttp://hdl.handle.net/1822/42485
DOI10.1088/2053-1591/3/7/075404
ISSN2053-1591
Versão da editorahttp://iopscience.iop.org/article/10.1088/2053-1591/3/7/075404
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
3B’s - Artigos em revistas/Papers in scientific journals

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