Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/42479

TítuloMicrofluidic production of hyaluronic acid derivative microfibers to control drug release
Autor(es)Agnello, Stefano
Gasperini, Luca
Reis, R. L.
Mano, J. F.
Pitarresi, Giovanna
Palumbo, Fabio S.
Giammona, Gaetano
Palavras-chaveBiomaterials
Polymers
Hyaluronic acid
Microfibers
Microfluidic technique
Polymers
Drug delivery
Data2016
EditoraElsevier
RevistaMaterials Letters
CitaçãoAgnello S., Gasperini L., Reis R. L., Mano J. F., Pitarresi G., Palumbo F. S., Giammona G. Microfluidic production of hyaluronic acid derivative microfibers to control drug release, Materials Letters, Vol. 182, pp. 309-313, doi:10.1016/j.matlet.2016.07.014, 2016
Resumo(s)Microfibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability oMicrofibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability of the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications.f the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications.
Tipoarticle
Descrição"Available online 4 July 2016"
URIhttp://hdl.handle.net/1822/42479
DOI10.1016/j.matlet.2016.07.014
ISSN0167-577X
Versão da editorahttp://www.sciencedirect.com/science/article/pii/S0167577X16311089
Arbitragem científicayes
AcessorestrictedAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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