Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/42479

TitleMicrofluidic production of hyaluronic acid derivative microfibers to control drug release
Author(s)Agnello, Stefano
Gasperini, Luca
Reis, R. L.
Mano, J. F.
Pitarresi, Giovanna
Palumbo, Fabio S.
Giammona, Gaetano
KeywordsBiomaterials
Polymers
Hyaluronic acid
Microfibers
Microfluidic technique
Polymers
Drug delivery
Issue date2016
PublisherElsevier
JournalMaterials Letters
CitationAgnello S., Gasperini L., Reis R. L., Mano J. F., Pitarresi G., Palumbo F. S., Giammona G. Microfluidic production of hyaluronic acid derivative microfibers to control drug release, Materials Letters, Vol. 182, pp. 309-313, doi:10.1016/j.matlet.2016.07.014, 2016
Abstract(s)Microfibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability oMicrofibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability of the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications.f the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications.
TypeArticle
Description"Available online 4 July 2016"
URIhttp://hdl.handle.net/1822/42479
DOI10.1016/j.matlet.2016.07.014
ISSN0167-577X
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S0167577X16311089
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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