Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/42050

TitleFabrication of anisotropically aligned nanofibrous scaffolds based on natural/synthetic polymer blends reinforced with cellulose nanocrystals for tendon tissue engineering
Author(s)Domingues, Rui Miguel Andrade
Chiera, Silvia
Gershovich, Pavel
Motta, Antonella
Reis, R. L.
Gomes, Manuela E.
KeywordsMechanical property
Nanocomposite
Nanofiber
Scaffold
Issue date2016
CitationDomingues R. M. A., Chiera S., Gershovich P., Motta A., Reis R. L., Gomes M. E. Fabrication of anisotropically aligned nanofibrous scaffolds based on natural/synthetic polymer blends reinforced with cellulose nanocrystals for tendon tissue engineering, Frontiers in Bioengineering and Biotechnology, doi:10.3389/conf.FBIOE.2016.01.01963, 2016
Abstract(s)[Excerpt] Introduction: Tendon disorders and injuries are among the most common musculoskeletal problems and their regeneration after injury remains a significant challenge. Given the prevalent fibrous nature of tendons’ ECM, which exhibits an aligned and hierarchical organization in structures from the nano to the macro scale, uniaxial aligned electrospun nanofibers produced from natural/synthetic polymer blends are among the most successful tendon scaffolds in tissue engineering (TE) strategies[1]. These biomaterials can provide the topographical cues to direct cell adhesion and proliferation, as well as positively affecting cell’s differentiation, phenotype maintenance and matrix deposition. However, the limited mechanical properties of electrospun biomaterials restrict their potential application in this field. In the present study, we propose the use of cellulose nanocrystals (CNCs), the “nature carbon nanotubes”, as a strategy for the reinforcement of electrospun poly­ɛ­caprolactone­chitosan (PCL­C) nanofiber scaffolds without compromising their biological performance and thus expand their potential range of application in tendon TE strategies. (...)
TypeAbstract
URIhttp://hdl.handle.net/1822/42050
DOI10.3389/conf.FBIOE.2016.01.01963
ISSN2296-4185
Publisher versionURL=http://www.frontiersin.org/Journal/FullText.aspx?f=7&name=bioengineering_and_biotechnology&ART_DOI=10.3389/conf.FBIOE.2016.01.01963
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Resumos em livros de atas de conferências - indexados no ISI Web of Science

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