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TitleProcessing and size range separation of pristine and magnetic poly(L-lactic acid) based microspheres for biomedical applications
Author(s)Correia, D. M.
Sencadas, Vítor João Gomes Silva
Ribeiro, C.
Martins, P. M.
Martins, P.
Gama, F. M.
Botelho, Gabriela
Lanceros-Méndez, S.
Poly(L-lactic acid) microspheres
Oil in water emulsion technique
Cell viability
Magnetic nanocomposites
Issue date2016
JournalJournal of Colloid and Interface Science
CitationCorreia, D. M.; Sencadas, V.; Ribeiro, C.; Martins, P.; Martins, P.; Gama, F. M.; Botelho, G.; Lanceros-Méndez, S., Processing and size range separation of pristine and magnetic poly(L-lactic acid) based microspheres for biomedical applications. Journal of Colloid and Interface Science, 476, 79-86, 2016
Abstract(s)Biodegradable poly(L-lactic acid) (PLLA) and PLLA/CoFe2O4 magnetic microspheres with average sizes ranging between 0.16 -3.9 m and 0.8-2.2 m, respectively, were obtained by an oil-in-water emulsion method using poly(vinyl alcohol) (PVA) solution as the emulsifier agent. The separation of the microspheres in different size ranges was then performed by centrifugation and the colloidal stability assessed at different pH values. Neat PLLA spheres are more stable in alkaline environments when compared to magnetic microspheres, both types being stable for pHs higher than 4, resulting in a colloidal suspension. On the other hand, in acidic environments the microspheres tend to form aggregates. The neat PLLA microspheres show a degree of crystallinity of 40% whereas the composite ones are nearly amorphous (17%). Finally, the biocompatibility was assessed by cell viability studies with MC3T3-E1 pre-osteoblast cells.
Description"Available online 11 May 2016"
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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