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TitlePulse wave velocity distribution in a cohort study: from arterial stiffness to early vascular aging
Author(s)Cunha, Pedro G.
Cotter, Jorge
Oliveira, Pedro
Vila, Isabel
Boutouyrie, Pierre
Laurent, Stéphane
Nilsson, Peter M.
Scuteri, Angelo
Sousa, Nuno
KeywordsArterial stiffness
Cardiovascular risk
Early vascular aging
Large artery
Pulse wave velocity
Issue dateJul-2015
JournalJournal of Hypertension
CitationCunha, P. G., Cotter, J., Oliveira, P., Vila, I., Boutouyrie, P., Laurent, S., ... & Sousa, N. (2015). Pulse wave velocity distribution in a cohort study: from arterial stiffness to early vascular aging. Journal of hypertension, 33(7), 1438-1445.
Abstract(s)BACKGROUND: By contrast with other southern European people, north Portuguese population registers an especially high prevalence of hypertension and stroke incidence. We designed a cohort study to identify individuals presenting accelerated and premature arterial aging in the Portuguese population. METHOD: Pulse wave velocity (PWV) was measured in randomly sampled population dwellers aged 18-96 years from northern Portugal, and used as a marker of early vascular aging (EVA). Of the 3038 individuals enrolled, 2542 completed the evaluation. RESULTS: Mean PWV value for the entire population was 8.4?m/s (men: 8.6?m/s; women: 8.2?m/s; P?<?0.02). The individuals were classified with EVA if their PWV was at least 97.5th percentile of z-score for mean PWV values adjusted for age (using normal European reference values as comparators). The overall prevalence of EVA was 12.5%; 26.1% of individuals below 30 years presented this feature and 40.2% of individuals in that same age strata were placed above the 90th percentile of PWV; and 18.7% of the population exhibited PWV values above 10?m/s, with male predominance (17.2% of men aged 40-49 years had PWV?>?10?m/s). Logistic regression models indicated gender differences concerning the risk of developing large artery damage, with women having the same odds of PWV above 10?m/s 10 years later than men. CONCLUSION: The population PWV values were higher than expected in a low cardiovascular risk area (Portugal). High prevalence rates of EVA and noteworthy large artery damage in young ages were found.
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AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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