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TitleFolate-targeted nanoparticles for rheumatoid arthritis therapy
Author(s)Nogueira, Eugénia Sofia Costa
Gomes, Andreia C.
Preto, Ana
Cavaco-Paulo, Artur
KeywordsDrug delivery
Rheumatoid arthritis
Issue dateMay-2016
JournalNanomedicine: Nanotechnology, Biology, and Medicine
CitationNogueira, E.; Gomes, Andreia C.; Preto, Ana; Paulo, Artur Cavaco, Folate-targeted nanoparticles for rheumatoid arthritis therapy. Nanomedicine: Nanotechnology, Biology, and Medicine, 12(4), 1113-1126, 2016
Abstract(s)Rheumatoid arthritis (RA) is the most common inflammatory rheumatic disease, affecting almost 1% of the world population. Although the cause of RA remains unknown, the complex interaction between immune mediators (cytokines and effector cells) is responsible for the joint damage that begins at the synovial membrane. Activated macrophages are critical in the pathogenesis of RA and have been shown to specifically express a receptor for the vitamin folic acid (FA), folate receptor (FR). This particular receptor allows internalization of FA-coupled cargo. In this review we will address the potential of nanoparticles as an effective drug delivery system for therapies that will directly target activated macrophages. Special attention will be given to stealth degree of the nanoparticles as a strategy to avoid clearance by macrophages of the mononuclear phagocytic system (MPS). This review summarizes the application of FA-target nanoparticles as drug delivery systems for RA and proposes prospective future directions.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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