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|Title:||Current approaches and future perspectives on strategies for the development of personalized tissue engineering therapies|
|Author(s):||Neves, Lisete S.|
Rodrigues, Márcia T.
Reis, R. L.
Gomes, Manuela E.
|Publisher:||Taylor and Francis|
|Journal:||Expert Review of Precision Medicine and Drug Development: Personalized Medicine in Drug Development and Clinical Practice|
|Citation:||Neves L. S., Rodrigues M. T., Reis R. L., Gomes M. E. Current approaches and future perspectives on strategies for the development of personalized tissue engineering therapies, Personalized medicine in drug development and clinical practice, Vol. 1, pp. 93–108, doi:10.1080/23808993.2016.1140004, 2016|
|Abstract(s):||Personalized tissue engineering and regenerative medicine (TERM) therapies propose patient-oriented effective solutions, considering individual needs. Cell-based therapies, for example, may benefit from cell sources that enable easier autologous set-ups or from recent developments on IPS cells technologies towards effective personalized therapeutics. Furthermore, the customization of scaffold materials to perfectly fit a patientâ s tissue defect through rapid prototyping technologies, also known as 3D printing, is now a reality. Nevertheless, the timing to expand cells or to obtain functionalÂ in vitrotissue substitutes prior to implantation prevents advancements towards routine use upon patientÂ´s needs. Thus, personalized therapies also anticipate the importance of creating off-the-shelf solutions to enable immediately available tissue engineered products. This paper reviews the main recent developments and future challenges to enable personalized TERM approaches and to bring these technologies closer to clinical applications.|
|Appears in Collections:||3B’s - Artigos em revistas/Papers in scientific journals|
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