Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/40927

TitleCurrent approaches and future perspectives on strategies for the development of personalized tissue engineering therapies
Author(s)Neves, Lisete S.
Rodrigues, Márcia T.
Reis, R. L.
Gomes, Manuela E.
KeywordsCell therapies
Cryo-banking
Cryopreservation
Customization
Off-the-shelf
Personalized medicine
Tissue engineering
Translational platforms
Issue date2016
PublisherTaylor & Francis
JournalExpert Review of Precision Medicine and Drug Development: Personalized Medicine in Drug Development and Clinical Practice
CitationNeves L. S., Rodrigues M. T., Reis R. L., Gomes M. E. Current approaches and future perspectives on strategies for the development of personalized tissue engineering therapies, Personalized medicine in drug development and clinical practice, Vol. 1, pp. 93–108, doi:10.1080/23808993.2016.1140004, 2016
Abstract(s)Personalized tissue engineering and regenerative medicine (TERM) therapies propose patient-oriented effective solutions, considering individual needs. Cell-based therapies, for example, may benefit from cell sources that enable easier autologous set-ups or from recent developments on IPS cells technologies towards effective personalized therapeutics. Furthermore, the customization of scaffold materials to perfectly fit a patientâ s tissue defect through rapid prototyping technologies, also known as 3D printing, is now a reality. Nevertheless, the timing to expand cells or to obtain functional in vitrotissue substitutes prior to implantation prevents advancements towards routine use upon patient´s needs. Thus, personalized therapies also anticipate the importance of creating off-the-shelf solutions to enable immediately available tissue engineered products. This paper reviews the main recent developments and future challenges to enable personalized TERM approaches and to bring these technologies closer to clinical applications.
TypeArticle
URIhttp://hdl.handle.net/1822/40927
DOI10.1080/23808993.2016.1140004
ISSN2380-8993
Publisher versionhttp://www.tandfonline.com/doi/abs/10.1080/23808993.2016.1140004
Peer-Reviewedno
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals


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