Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/40842

TitleThe effect of high-fat diet on rat’s mood, feeding behavior and response to stress
Author(s)Aslani, Shilan
Vieira, Neide
Marques, Fernanda
Costa, Patrício Soares
Sousa, Nuno
Palha, Joana Almeida
Issue dateNov-2015
PublisherNature Publishing Group
JournalTranslational Psychiatry
CitationAslani, S., Vieira, N., Marques, F., Costa, P. S., Sousa, N., & Palha, J. A. (2015). The effect of high-fat diet on rat’s mood, feeding behavior and response to stress. Translational Psychiatry, 5(11)
Abstract(s)An association between obesity and depression has been indicated in studies addressing common physical (metabolic) and psychological (anxiety, low self-esteem) outcomes. Of consideration in both obesity and depression are chronic mild stressors to which individuals are exposed to on a daily basis. However, the response to stress is remarkably variable depending on numerous factors, such as the physical health and the mental state at the time of exposure. Here a chronic mild stress (CMS) protocol was used to assess the effect of high-fat diet (HFD)-induced obesity on response to stress in a rat model. In addition to the development of metabolic complications, such as glucose intolerance, diet-induced obesity caused behavioral alterations. Specifically, animals fed on HFD displayed depressive- and anxious-like behaviors that were only present in the normal diet (ND) group upon exposure to CMS. Of notice, these mood impairments were not further aggravated when the HFD animals were exposed to CMS, which suggest a ceiling effect. Moreover, although there was a sudden drop of food consumption in the first 3 weeks of the CMS protocol in both ND and HFD groups, only the CMS-HFD displayed an overall noticeable decrease in total food intake during the 6 weeks of the CMS protocol. Altogether, the study suggests that HFD impacts on the response to CMS, which should be considered when addressing the consequences of obesity in behavior.
TypeArticle
URIhttp://hdl.handle.net/1822/40842
DOI10.1038/tp.2015.178
ISSN2158-3188
Publisher versionhttp://www.nature.com/tp/journal/v5/n11/abs/tp2015178a.html
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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