Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/40815

TítuloChondrogenic potential of injectable κ-carrageenan hydrogel with encapsulated adipose stem cells for cartilage tissue-engineering applications
Autor(es)Popa, Elena Geta
Caridade, Sofia Glória Ferreira
Mano, J. F.
Reis, R. L.
Gomes, Manuela E.
Palavras-chaveAdipose-derived stem cells
Chondrogenic differentiation
mechanical properties
RevistaJournal of Tissue Engineering and Regenerative Medicine
CitaçãoPopa E. G., Caridade S. G., Mano J. F., Reis R. L., Gomes M. E. Chondrogenic potential of injectable κ-carrageenan hydrogel with encapsulated adipose stem cells for cartilage tissue-engineering applications, Journal of Tissue Engineering and Regenerative Medicine, Vol. 9, Issue 5, pp. 550-563, doi:10.1002/term.1683, 2015
Resumo(s)Due to the limited self-repair capacity of cartilage, regenerative medicine therapies for the treatment of cartilage defects must use a significant amount of cells, preferably applied using a hydrogel system that can promise their delivery and functionality at the specific site. This paper discusses the potential use of k-carrageenan hydrogels for the delivery of stem cells obt ained from adipose tissue in the treatment of cartilage tissue defects. The developed hydrogels were produced by an ionotropic gelation met hod and human adipose stem cells (hASCs) were encapsulated in 1.5% w/v k-carrageenan solution at a cell density of 5  10 6 cells/ml. The results from the analysis of the cell-encapsulating hydrogels, cultured for up to 21 days, indicated that k-carrageenan hydrogels support the viability, proliferation and chondrogenic differentiation of hASCs. Additionally, the mec hanical analysis demonstrated an increase in stiffness and viscoelastic properties of k-carrageenan gels with their encapsulated cells with increasing time in culture with chondrogenic medium. These results allowed the conclusion that k-carrageenan exhibits properties t hat enable the in vitro functionality of encapsulated hASCs and thus may provide the basis for new successful approaches for the treatment of cartilage defects.
Versão da editorahttp://onlinelibrary.wiley.com/doi/10.1002/term.1683/full
Arbitragem científicayes
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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