Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/40810

TitleLipids under stress - a lipidomic approach for the study of mood disorders
Author(s)Miranda, André Miguel Lopes
Oliveira, Tiago Gil
Keywordsbrain
chronic stress
lipid
lipidomics
mass spectrometry
mood disorders
Issue date2015
PublisherWiley
JournalBioEssays
CitationMiranda, A. M., & Oliveira, T. G. (2015). Lipids under stress - A lipidomic approach for the study of mood disorders. BioEssays, 37(11), 1226-1235. doi: 10.1002/bies.201500070
Abstract(s)The emerging field of lipidomics has identified lipids as key players in disease physiology. Their physicochemical diversity allows precise control of cell structure and signaling events through modulation of membrane prop- erties and trafficking of proteins. As such, lipids are important regulators of brain function and have been implicated in neurodegenerative and mood disorders. Importantly, environmental chronic stress has been associated with anxiety and depression and its exposure in rodents has been extensively used as a model to study these diseases. With the accessibility to modern mass- spectrometry lipidomic platforms, it is now possible to snapshot the extensively interconnected lipid network. Here, we review the fundamentals of lipid biology and outline a framework for the interpretation of lipidomic studies as a new approach to study brain pathophysiology. Thus, lipid profiling provides an exciting avenue for the identification of disease signatures with important implications for diagnosis and treatment of mood disorders.
TypeArticle
URIhttp://hdl.handle.net/1822/40810
DOI10.1002/bies.201500070
ISSN0265-9247
Publisher versionhttp://onlinelibrary.wiley.com/
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
miranda_et_al-2015-bioessays (1).pdf445,09 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID