Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/40668

TítuloPresence of starch enhances in vitro biodegradation and biocompatibility of a gentamicin delivery formulation
Autor(es)Balmayor, E. R.
Baran, T. E.
Unger, M.
Marques, A. P.
Azevedo, H. S.
Reis, R. L.
Palavras-chavecytotoxicity
enzymatic degradation
gentamicin
microparticles
Starch-conjugated chitosan
Data2015
EditoraWiley
RevistaJournal of Biomedical Materials Research Part B: Applied Biomaterials
CitaçãoBalmayor, E. R., Baran, T. E., Unger, M., Marques, A. P., Azevedo, H. S., & Reis, R. L. (2015). Presence of starch enhances in vitro biodegradation and biocompatibility of a gentamicin delivery formulation. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 103(8), 1610-1620. doi: 10.1002/jbm.b.33343
Resumo(s)The effect of α-amylase degradation on the release of gentamicin from starch-conjugated chitosan microparticles was investigated up to 60 days. Scanning electron microscopic observations showed an increase in the porosity and surface roughness of the microparticles as well as reduced diameters. This was confirmed by 67% weight loss of the microparticles in the presence of α-amylase. Over time, a highly porous matrix was obtained leading to increased permeability and increased water uptake with possible diffusion of gentamicin. Indeed, a faster release of gentamicin was observed with α-amylase. Starch-conjugated chitosan particles are non-toxic and highly biocompatible for an osteoblast (SaOs-2) and fibroblast (L929) cell line as well as adipose-derived stem cells. When differently produced starch-conjugated chitosan particles were tested, their cytotoxic effect on SaOs-2 cells was found to be dependent on the crosslinking agent and on the amount of starch used.
Tipoarticle
URIhttp://hdl.handle.net/1822/40668
DOI10.1002/jbm.b.33343
ISSN1552-4981
Versão da editorahttp://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33343/abstract
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals


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