Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/40580

TitleMicro- and mesoporous structures as drug delivery carriers for salicylic acid
Author(s)Vilaça, Natália
Santos, Filipa Morais
Machado, Ana F.
Sirkecioğlu, Ahmet
Pereira, Manuel F. R.
Sardo, Mariana
Rocha, João
Parpot, Pier
Fonseca, A. M.
Baltazar, Fátima
Neves, Isabel C.
Issue date2015
PublisherAmerican Chemical Society
JournalJournal of Physical Chemistry C
CitationVilaca, N., Morais-Santos, F., Machado, A. F., Sirkecioğlu, A., Pereira, M. F. R., Sardo, M., . . . Neves, I. C. (2015). Micro- and Mesoporous Structures as Drug Delivery Carriers for Salicylic Acid. Journal of Physical Chemistry C, 119(7), 3589-3595. doi: 10.1021/jp5117849
Abstract(s)The potential of salicylic acid (SA) encapsulated in porous materials as drug delivery carriers for cancer treatment was studied. Different porous structures, the microporous zeolite NaY, and the mesoporous SBA-15 and MCM-41 were used as hosts for the anti-inflammatory drug. Characterization with different techniques (FTIR, UV/vis, TGA, 1H NMR, and 13C CPMAS NMR) demonstrated the successful loading of SA into the porous hosts. The mesoporous structures showed to be very efficient to encapsulate the SA molecule. The obtained drug delivery systems (DDS) accommodated 0.74 mmol (341 mg/gZEO) in NaY and 1.07 mmol (493 mg/gZEO) to 1.23 mmol (566 mg/gZEO) for SBA-15 and MCM-41, respectively. Interactions between SA molecules and pore structures were identified. A fast and unrestricted liberation of SA at 10 min of the dissolution assay was achieved with 29.3, 46.6, and 50.1 µg/mL of SA from NaY, SBA-15, and MCM-41, respectively, in the in vitro drug release studies (PBS buffer pH 7.4, 37 °C). Kinetic modeling was used to determine the release patterns of the DDS. The porous structures and DDS were evaluated on Hs578T and MDA-MB-468 breast cancer cell lines viability. The porous structures are nontoxic to cancer cells. Cell viability reduction was only observed after the release of SA from MCM- 41 followed by SBA-15 in both breast cancer cell lines.
TypeArticle
URIhttp://hdl.handle.net/1822/40580
DOI10.1021/jp5117849
ISSN1932-7447
Publisher versionhttp://pubs.acs.org/doi/abs/10.1021/jp5117849
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CDQuim - Artigos (Papers)
ICVS - Artigos em Revistas Internacionais com Referee

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