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TitleThe diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance?
Author(s)Rossi, Esther Diana
Bizzarro, Tommaso
Longatto Filho, Adhemar
Gerhard, Rene
Schmitt, Fernando
Liquid-based cytology
Molecular analysis
Nodular lesions
targeted therapies
Issue date2015
PublisherTaylor & Francis
JournalExpert Review of Anticancer Therapy
CitationRossi, E. D., Bizzarro, T., Longatto-Filho, A., Gerhard, R., & Schmitt, F. (2015). The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance? Expert Review of Anticancer Therapy, 15(8), 911-921. doi: 10.1586/14737140.2015.1053874
Abstract(s)Here, we evaluate the diagnostic and prognostic role of liquid-based cytology (LBC) in different body lesions, including thyroid, lung, effusions and malignant breast lesions. LBC has gained consensus after being applied to both non-gynecologic and fine-needle aspiration cytology. Although some remain sceptical regarding the diagnostic efficacy of LBC, mainly when used alone, in recent years, good results have been obtained as long as it showed a high diagnostic accuracy. Here, we discuss the additional possibility of storing material for the application of ancillary techniques (immunocytochemistry–molecular analysis) with several diagnostic and prognostic advantages, which may pave the way for the challenging evaluation of both monitoring responses to treatment and resistance to targeted therapies in thyroid, lung, breast carcinoma or malignant effusions. Furthermore, it provides the use of several molecular spots as specific targets for personalized therapy.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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