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TitlePolysaccharide-based freestanding multilayered membranes exhibiting reversible switchable properties
Author(s)Silva, Joana M.
Caridade, S. G.
Reis, R. L.
Mano, J. F.
Calcium-induced adhesion
Dynamic mechanical analysis
Issue date2016
PublisherRoyal Society of Chemistry
JournalSoft Matter
CitationSilva J. M., Caridade S. G., Reis R. L., Mano J. F. Polysaccharide-based freestanding multilayered membranes exhibiting reversible switchable properties, Soft Matter, doi:10.1039/C5SM02458G, 2016.
Abstract(s)The design of self-standing multilayered structures based on biopolymers has been attracting increasing interest due to their potential in the biomedical field. However, their use has been limited due to their gel-like properties. Herein, we report the combination of covalent and ionic cross-linking, using natural and non-cytotoxic cross-linkers, such as genipin and calcium chloride (CaCl2). Combining both cross-linking types the mechanical properties of the multilayers increased and the water uptake ability decreased. The ionic cross-linking of multilayered chitosan (CHI)â alginate (ALG) films led to freestanding membranes with multiple interesting properties, such as: improved mechanical strength, calcium-induced adhesion and shape memory ability. The use of CaCl2 also offered the possibility of reversibly switching all of these properties by simple immersion in a chelate solution. We attribute the switch-ability of the mechanical properties, shape memory ability and the propensity for induced-adhesion to the ionic cross-linking of the multilayers. These findings suggested the potential of the developed polysaccharide freestanding membranes in a plethora of research fields, including in biomedical and biotechnological fields.
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Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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