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dc.contributor.authorRodrigues, L. C.por
dc.contributor.authorCustódio, Catarina A.por
dc.contributor.authorReis, R. L.por
dc.contributor.authorMano, J. F.por
dc.identifier.citationRodrigues L. C., Custódio C. A., Reis R. L., Mano J. F. Light responsive multilayer surfaces with controlled spatial extinction capability, J. Mater. Chem. B, doi:10.1039/C5TB02606G, 2016por
dc.description.abstractMultilayer systems obtained using the Layer-by-Layer (LbL) technology have been proposed for a variety of biomedical applications in tissue engineering and regenerative medicine. LbL assembly is a simple and highly versatile method to modify surfaces and fabricate robust and highly-ordered nanostructured coatings over almost any type of substrates and with a wide range of substances. The incorporation of polyoxometalate (POM) inorganic salts as constituents of the layers presents a possibility of promoting light-stimuli responses in LbL substrates. We propose the design of a biocompatible photo-responsive multilayer system based on a Preyssler-type POM ([NaP5W30O110]14â ) and a natural origin polymer, chitosan, using the LbL methodology. The photo-reduction properties of the POM allow the spatially controlled disruption of the assembled layers due to the weakening of the electrostatic interactions between the layers. This system has found applicability in detaching devices, such as the cell sheet technology, which may solve the drawbacks actually found in other cell treatment proposals.por
dc.description.sponsorshipThe authors are pleased to acknowledge "Novel smart and biomimetic materials for innovative regenerative medicine approaches" (Ref.: RL1 - ABMR - NORTE-01-0124-FEDER-000016) co-financed by the North Portugal Regional Operational Programme (ON.2 - O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF). L. C. Rodrigues specially acknowledges Portuguese Fundacao para a Ciencia e Tecnologia for the individual Grant SFRH/BPD/93697/2013.por
dc.publisherRoyal Society of Chemistrypor
dc.subjectCell Sheetpor
dc.subjectFree-standing membranepor
dc.subjectLight stimulipor
dc.subjectNatural origin polymerspor
dc.titleLight responsive multilayer surfaces with controlled spatial extinction capabilitypor
oaire.citationTitleJournal of Materials Chemistry Bpor
dc.subject.wosScience & Technologypor
sdum.journalJournal of Materials Chemistry Bpor
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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