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TitleLight responsive multilayer surfaces with controlled spatial extinction capability
Author(s)Rodrigues, L. C.
Custódio, Catarina A.
Reis, R. L.
Mano, J. F.
KeywordsCell Sheet
Free-standing membrane
Light stimuli
Natural origin polymers
Issue dateJan-2016
PublisherRoyal Society of Chemistry
JournalJournal of Materials Chemistry B
CitationRodrigues L. C., Custódio C. A., Reis R. L., Mano J. F. Light responsive multilayer surfaces with controlled spatial extinction capability, J. Mater. Chem. B, doi:10.1039/C5TB02606G, 2016
Abstract(s)Multilayer systems obtained using the Layer-by-Layer (LbL) technology have been proposed for a variety of biomedical applications in tissue engineering and regenerative medicine. LbL assembly is a simple and highly versatile method to modify surfaces and fabricate robust and highly-ordered nanostructured coatings over almost any type of substrates and with a wide range of substances. The incorporation of polyoxometalate (POM) inorganic salts as constituents of the layers presents a possibility of promoting light-stimuli responses in LbL substrates. We propose the design of a biocompatible photo-responsive multilayer system based on a Preyssler-type POM ([NaP5W30O110]14â ) and a natural origin polymer, chitosan, using the LbL methodology. The photo-reduction properties of the POM allow the spatially controlled disruption of the assembled layers due to the weakening of the electrostatic interactions between the layers. This system has found applicability in detaching devices, such as the cell sheet technology, which may solve the drawbacks actually found in other cell treatment proposals.
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AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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