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TitleEvaluating biomaterial-and microfluidic-based 3D tumor models
Author(s)Carvalho, Mariana R.
Lima, Daniela
Reis, R. L.
Correlo, V. M.
Oliveira, J. M.
Cancer microenvironment
Drug discovery
Issue dateOct-2015
JournalTrends in Biotechnology
CitationCarvalho M. R., Daniela L., Reis R. L., Correlo V. M., Oliveira J. M. Evaluating Biomaterial-and Microfluidic-Based 3D Tumor Models, Trends in Biotechnology, Vol. 33, Issue 11, pp. 667–678, doi:10.1016/j.tibtech.2015.09.009, 2015
Abstract(s)Cancer is a major cause of morbidity and mortality worldwide, with a disease burden estimated to increase in the coming decades. Disease heterogeneity and limited information on cancer biology and disease mechanisms are aspects that 2D cell cultures fail to address. We review the current "state-of-the-art" in 3D Tissue Engineering (TE) models developed for and used in cancer research. Scaffold-based TE models and microfluidics, are assessed for their potential to fill the gap between 2D models and clinical application. Recent advances in combining the principles of 3D TE models and microfluidics are discussed, with a special focus on biomaterials and the most promising chip-based 3D models.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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