Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/40282

TítuloKi-67 expression in CRC lymph node metastasis does not predict survival
Autor(es)Martins, Sandra
Amorim, Ricardo
Mota, Sílvia Coelho
Costa, Luís
Pardal, Fernando
Rodrigues, Mesquita
Longatto Filho, Adhemar
Data2015
EditoraHindawi Publishing Corporation
RevistaBioMed Research International
CitaçãoMartins, S. F., Amorim, R., Mota, S. C., Costa, L., Pardal, F., Rodrigues, M., & Longatto-Filho, A. (2015). Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival. BioMed Research International, 2015. doi: 10.1155/2015/131685
Resumo(s)Colorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumourassociated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained byKi-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division.
Tipoarticle
URIhttp://hdl.handle.net/1822/40282
DOI10.1155/2015/131685
ISSN2314-6133
Versão da editorahttp://www.hindawi.com/journals/bmri/aa/131685/
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

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