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dc.contributor.authorMartinho, Olgapor
dc.contributor.authorVilaça, Natáliapor
dc.contributor.authorCastro, Paulo J. G.por
dc.contributor.authorAmorim, Ricardopor
dc.contributor.authorFonseca, António M.por
dc.contributor.authorBaltazar, Fátimapor
dc.contributor.authorReis, R. M.por
dc.contributor.authorNeves, Isabel C.por
dc.identifier.citationMartinho, O., Vilaca, N., Castro, P. J. G., Amorim, R., Fonseca, A. M., Baltazar, F., . . . Neves, I. C. (2015). In vitro and in vivo studies of temozolomide loading in zeolite structures as drug delivery systems for glioblastoma. Rsc Advances, 5(36), 28219-28227. doi: 10.1039/c5ra03871e-
dc.description.abstractZeolites Y (faujasite) and MOR (mordonite) were used as hosts for temozolomide (TMZ), a current good-standard chemotherapeutic agent used in the treatment of glioblastoma brain tumors. TMZ was loaded into zeolites by liquid-phase adsorption at controlled pH. FTIR, 1H NMR, MS, SEM, UV/vis and chemical analysis demonstrated the successful loading of TMZ into zeolite hosts. The hydrolysis of TMZ in MTIC (TMZ metabolite) after the preparation of drug delivery systems (DDS) was observed in simulated body fluid. The effect of zeolites and DDS were evaluated on the viability of glioblastoma cell lines. Unloaded Y zeolite presented toxicity to cancer cells in contrast to MOR. In accordance, the best results in potentiation of the TMZ effect was obtained with MOR. We found that mordonite loaded with 0.026 mmol of TMZ was able to decrease the half maximal inhibitory concentrations (IC50) at least 3-fold in comparison to free temozolomide both in vitro and in vivo.por
dc.description.sponsorshipR.A. and N.V. are recipients of PhD fellowships (SFRH/BI/51118/2010 and SFRH/BD/97797/2013) from Fundacao para a Ciencia e a Tecnologia (FCT, Portugal). O.M. is a recipient of a Post-Doc fellowship (UMINHO/BPD/32/2013) from QREN. The authors thank the FCT and FEDER-COMPETE-QREN-EU for financial support to the Research Centers, CQ/UM, PEst-C/QUI/UI0686/2013 (F-COMP-01-0124-FEDER-037302) and Life and Health Sciences Research Institute (ICVS, University of Minho, Portugal). The NMR spectrometer is part of the National NMR Network (RNRMN), supported with funds from FCT/QREN (Quadro de Referencia Estrategico Nacional).por
dc.publisherRoyal Soc Chemistrypor
dc.titleIn vitro and in vivo studies of temozolomide loading in zeolite structures as drug delivery systems for glioblastomapor
degois.publication.titleRoyal Society of Chemistry Advancespor
dc.subject.wosScience & Technologypor
sdum.journalRoyal Society of Chemistry Advancespor
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