Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/40150

TitleBacterial vaginosis biofilms: challenges to current therapies and emerging solutions
Author(s)Machado, D.
Castro, J.
Oliveira, Ana Palmeira de
Oliveira, José Martinez de
Cerca, Nuno
KeywordsBacterial vaginosis
Biofilms
Gardnerella vaginalis
Antibiotics
Emerging therapies
Issue date20-Jan-2016
PublisherFrontiers Media
JournalFrontiers in Microbiology
CitationMachado, D.; Castro, J.; Palmeira-de-Oliveira, Ana; Martinez-de-Oliveira, José; Cerca N, Bacterial vaginosis biofilms: challenges to current therapies and emerging solutions. Frontiers in Microbiology, 6(1528), 1-13, 2016
Abstract(s)Bacterial vaginosis (BV) is the most common genital tract infection in women during their reproductive years and it has been associated with serious health complications, such as preterm delivery and acquisition or transmission of several sexually transmitted agents. BV is characterized by a reduction of beneficial lactobacilli and a significant increase in number of anaerobic bacteria, including Gardnerella vaginalis, Atopobium vaginae, Mobiluncus spp., Bacteroides spp. and Prevotella spp.. Being polymicrobial in nature, BV etiology remains unclear. However, it is certain that BV involves the presence of a thick vaginal multi-species biofilm, where G. vaginalis is the predominant species. Similar to what happens in many other biofilm-related infections, standard antibiotics, like metronidazole, are unable to fully eradicate the vaginal biofilm, which can explain the high recurrence rates of BV. Furthermore, antibiotic therapy can also cause a negative impact on the healthy vaginal microflora. These issues sparked the interest in developing alternative therapeutic strategies. This review provides a quick synopsis of the currently approved and available antibiotics for BV treatment while presenting an overview of novel strategies that are being explored for the treatment of this disorder, with special focus on natural compounds that are able to overcome biofilm-associated antibiotic resistance.
TypeArticle
URIhttp://hdl.handle.net/1822/40150
DOI10.3389/fmicb.2015.01528
ISSN1664-302X
e-ISSN1664-302X
Publisher versionhttp://journal.frontiersin.org/journal/microbiology
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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