Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/40144

TítuloInferior frontal gyrus white matter abnormalities in obsessive-compulsive disorder
Autor(es)Gonçalves, Óscar F.
Sousa, Sónia
Maia, Liliana Filipa Costa
Carvalho, Sandra Conceição Ribeiro
Leite, Jorge
Ganho, Ana
Gonçalves, Ana Fernandes
Frank, Brandon
Pocinho, Fernando
Carracedo, Ángel
Sampaio, Adriana
Palavras-chaveconnectivity
inferior frontal gyrus
obsessive-compulsive disorder
pars opercularis
pars orbitalis
pars triangularis
Data2015
EditoraKluwer
RevistaNeuroReport
CitaçãoGoncalves, Ó. F., Sousa, S., Maia, L., Carvalho, S., Leite, J., Ganho, A., . . . Sampaio, A. (2015). Inferior frontal gyrus white matter abnormalities in obsessive-compulsive disorder. NeuroReport, 26(9), 495-500. doi: 10.1097/wnr.0000000000000377
Resumo(s)The aim of the present study is to explore obsessive-compulsive disorder (OCD)-related abnormalities in white matter connectivity in OCD for a core region associated with inhibitory control [i.e. inferior frontal gyrus (IFG)]. Fifteen patients with OCD (11 men) and 15 healthy controls (nine men) underwent diffusion tensor imaging scanning to study four diffusivity indexes of white matter integrity [fractional anisotropy, mean diffusivity (MD), axial diffusivity and radial diffusivity (RD)]. The results showed that persons with OCD manifested significantly lower fractional anisotropy levels in the bilateral IFG as well as its parcellations in the pars opercularis, pars triangularis, and pars orbitalis. Significantly higher levels of MD, RD were evident for the OCD group in the IFG as a whole as well as in the bilateral subregions of the pars triangularis and pars opercularis (for MD and RD), the right side of the pars orbitalis (for RD), and the left side of the pars triangularis and right side pars opercularis (for axial diffusivity). Overall, the results suggest significant alterations in structural connectivity, probably associated with myelination and axonal abnormalities in the IFG of OCD patients.
Tipoarticle
URIhttp://hdl.handle.net/1822/40144
DOI10.1097/WNR.0000000000000377
ISSN0959-4965
1473-558X
Arbitragem científicayes
AcessorestrictedAccess
Aparece nas coleções:CIPsi - Artigos (Papers)

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Inferior_Frontal_gyrus.pdf172,52 kBAdobe PDFVer/Abrir  Solicitar cópia ao autor!

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu Currículo DeGóis