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TitleMosaic maternal ancestry in the Great Lakes region of East Africa
Author(s)Gomes, Verónica
Pala, Maria
Salas, Antonio
Álvarez‑Iglesias, Vanesa
Amorim, António
Gómez‑Carballa, Alberto
Carracedo, Ángel
Clarke, Douglas J.
Hill, Catherine
Mormina, Maru
Shaw, Marie‑Anne
Dunne, David W.
Pereira, Rui
Pereira, Vânia
Prata, Maria João
Sánchez‑Diz, Paula
Rito, Teresa
Soares, Pedro
Gusmão, Leonor
Richards, Martin B.
Issue date2015
JournalHuman Genetics
CitationGomes, V., Pala, M., Salas, A., Alvarez-Iglesias, V., Amorim, A., Gomez-Carballa, A., . . . Richards, M. B. (2015). Mosaic maternal ancestry in the Great Lakes region of East Africa. Human Genetics, 134(9), 1013-1027. doi: 10.1007/s00439-015-1583-0
Abstract(s)The Great Lakes lie within a region of East Africa with very high human genetic diversity, home of many ethno-linguistic groups usually assumed to be the product of a small number of major dispersals. However, our knowledge of these dispersals relies primarily on the inferences of historical, linguistics and oral traditions, with attempts to match up the archaeological evidence where possible. This is an obvious area to which archaeogenetics can contribute, yet Uganda, at the heart of these developments, has not been studied for mitochondrial DNA (mtDNA) variation. Here, we compare mtDNA lineages at this putative genetic crossroads across 409 representatives of the major language groups: Bantu speakers and Eastern and Western Nilotic speakers. We show that Uganda harbours one of the highest mtDNA diversities within and between linguistic groups, with the various groups significantly differentiated from each other. Despite an inferred linguistic origin in South Sudan, the data from the two Nilotic-speaking groups point to a much more complex history, involving not only possible dispersals from Sudan and the Horn but also large-scale assimilation of autochthonous lineages within East Africa and even Uganda itself. The Eastern Nilotic group also carries signals characteristic of West-Central Africa, primarily due to Bantu influence, whereas a much stronger signal in the Western Nilotic group suggests direct West-Central African ancestry. Bantu speakers share lineages with both Nilotic groups, and also harbour East African lineages not found in Western Nilotic speakers, likely due to assimilating indigenous populations since arriving in the region ~3000 years ago.
Publisher version
AccessOpen access
Appears in Collections:DBio - Artigos/Papers
ICVS - Artigos em Revistas Internacionais com Referee

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