Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/40045

TítuloFrom the periphery to the brain: Lipocalin-2, a friend or foe?
Autor(es)Ferreira, Ana Catarina
Mesquita, Sandro Gabriel Ferreira Dá
Sousa, João Carlos
Neves, Margarida Correia
Sousa, Nuno
Palha, Joana Almeida
Marques, Fernanda
Palavras-chaveLipocalin-2
Astrocytes
Central nervous system
Multiple sclerosis
Alzheimer’s disease
Iron
Data2015
EditoraElsevier
RevistaProgress in Neurobiology
CitaçãoFerreira, A. C., Da Mesquita, S., Sousa, J. C., Correia-Neves, M., Sousa, N., Palha, J. A., & Marques, F. (2015). From the periphery to the brain: Lipocalin-2, a friend or foe? Progress in Neurobiology, 131, 120-136. doi: 10.1016/j.pneurobio.2015.06.005
Resumo(s)Lipocalin-2 (LCN2) is an acute-phase protein that, by binding to iron-loaded siderophores, acts as a potent bacteriostatic agent in the iron-depletion strategy of the immune system to control pathogens. The recent identification of a mammalian siderophore also suggests a physiological role for LCN2 in iron homeostasis, specifically in iron delivery to cells via a transferrin-independent mechanism. LCN2 participates, as well, in a variety of cellular processes, including cell proliferation, cell differentiation and apoptosis, and has been mostly found up-regulated in various tissues and under inflammatory states, being its expression regulated by several inducers. In the central nervous system less is known about the processes involving LCN2, namely by which cells it is produced/secreted, and its impact on cell proliferation and death, or in neuronal plasticity and behaviour. Importantly, LCN2 recently emerged as a potential clinical biomarker in multiple sclerosis and in ageing-related cognitive decline. Still, there are conflicting views on the role of LCN2 in pathophysiological processes, with some studies pointing to its neurodeleterious effects, while others indicate neuroprotection. Herein, these various perspectives are reviewed and a comprehensive and cohesive view of the general function of LCN2, particularly in the brain, is provided.
Tipoarticle
URIhttp://hdl.handle.net/1822/40045
DOI10.1016/j.pneurobio.2015.06.005
ISSN0301-0082
Versão da editorahttp://www.sciencedirect.com/science/journal/03010082
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

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