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TitleEffector memory CD4+ T cells are associated with cognitive performance in a senior population
Author(s)Miranda, Cláudia Serre
Roque, Susana
Santos, Nadine Correia
Nunes, José Carlos Leitão Portugal
Costa, Patrício Soares
Palha, Joana Almeida
Sousa, Nuno
Neves, Margarida Correia
Issue date2015
PublisherLippincott, Williams and Wilkins
JournalJournal of American Academy of Neurology
Abstract(s)Objective: Immunosenescence and cognitive decline are common markers of the aging process. Taking into consideration the heterogeneity observed in aging processes and the recently described link between lymphocytes and cognition, we herein explored the possibility of an association between alterations in lymphocytic populations and cognitive performance. Methods: In a cohort of cognitively healthy adults (n = 114), previously characterized by diverse neurocognitive/psychological performance patterns, detailed peripheral blood immunophenotyping of both the innate and adaptive immune systems was performed by flow cytometry. Results: Better cognitive performance was associated with lower numbers of effector memory CD4(+) T cells and higher numbers of naive CD8(+) T cells and B cells. Furthermore, effector memory CD4(+) T cells were found to be predictors of general and executive function and memory, even when factors known to influence cognitive performance in older individuals (e.g., age, sex, education, and mood) were taken into account. Conclusions: This is the first study in humans associating specific phenotypes of the immune system with distinct cognitive performance in healthy aging.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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