Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/39814

TitleIs honey able to potentiate the antioxidant and cytotoxic properties of medicinal plants consumed as infusions for hepatoprotective effects?
Author(s)Pereira, C.
Barreira, J. C. M.
Calhelha, Ricardo C.
Lopes, Melissa
Queiroz, Maria João R. P.
Vilas-Boas, Miguel
Barros, Lillian
Ferreira, Isabel C. F. R.
KeywordsMedicinal plants
Antioxidant activity
Hepatotoxicity
Synergism
Linear 38 discriminant analysis
Issue date2015
PublisherRoyal Society of Chemistry
JournalFood and Function
CitationPereira, C., Barreira, J. C. M., Calhelha, R. C., Lopes, M., Queiroz, M. J. R. P., Vilas-Boas, M., . . . Ferreira, I. C. F. R. (2015). Is honey able to potentiate the antioxidant and cytotoxic properties of medicinal plants consumed as infusions for hepatoprotective effects? Food & Function, 6(5), 1435-1442. doi: 10.1039/c4fo01206b
Abstract(s)Due to the enormous variety of phytochemicals present in plants, their extracts have been used for centuries in the treatment of innumerous diseases, being perceived as an invaluable source of medicines for humans. Furthermore, the combination of different plants was reported as inducing an improved effect (synergism) in comparison to the additive activity of the plants present in those mixtures. Nevertheless, information regarding the effects of plant infusions added with honey is still rather scarce. Accordingly, the aim of this study was evaluating the interaction between chestnut honey, a natural product with well-reported beneficial properties, and three medicinal plants (either as single plant or as combinations of two and three plants), with regard to their antioxidant activity and hepatotoxicity. Antioxidant activity was evaluated by comparing the results from four different assays; the hepatotoxicity was assessed in two different cell lines. Results were compared by analysis of variance and linear discriminant analysis. The addition of honey to the infusions had a beneficial result in both cases, producing a synergistic effect in all samples, except beta-carotene bleaching inhibition for artichoke+milk thistle+honey preparation and also preparations with lower hepatotoxicity, except in the case of artichoke+honey. Moreover, from discriminant linear analysis output, it became obvious that the effect of honey addition overcame that resulting from using single plant or mixed plants based infusions. Also, the enhanced antioxidant activity of infusions containing honey was convoyed by a lower hepatotoxicity.
TypeArticle
URIhttp://hdl.handle.net/1822/39814
DOI10.1039/c4fo01206b
ISSN2212-4292
Publisher versionhttp://dx.doi.org/10.1039/c4fo01206b
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CDQuim - Artigos (Papers)

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