Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/39811

TitleChemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities
Author(s)Ferreira, Isabel C. F. R.
Heleno, S. A.; Stojkovicd, S.
Reis, F.
Stojkovicd, S.
Queiroz, Maria João R. P.
Vasconcelos, M. H.
Sokovic, M.
KeywordsGanoderma;
Polysaccharides
Chemical features
Bioactivity
Structure-activity
Issue date2015
PublisherElsevier
JournalPhytochemistry
CitationFerreira, I. C. F. R., Heleno, S. A., Reis, F. S., Stojkovic, D., Queiroz, M. J. R. P., Vasconcelos, M. H., & Sokovic, M. (2015). Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities. Phytochemistry, 114, 38-55. doi: 10.1016/j.phytochem.2014.10.011
Abstract(s)Ganoderma genus comprises one of the most commonly studied species worldwide, G. lucidum. However, other Ganoderma species have been also reported as important sources of bioactive compounds. Polysaccharides are important contributors to the medicinal properties reported for Ganoderma species, as demonstrated by the numerous publications, including reviews, on this matter. Yet, what are the chemical features of Ganoderma polysaccharides that have bioactivity? In the present manuscript, the chemical features of Ganoderma polysaccharides with reported antioxidant, antitumor and antimicrobial activities (the most studied worldwide) are analyzed in detail. The composition of sugars (homo- versus hetero-glucans and other polysaccharides), type of glycosidic linkages, branching patterns, and linkage to proteins are discussed. Methods for extraction, isolation and identification are evaluated and, finally, the bioactivity of polysaccharidic extracts and purified compounds are discussed. The integration of data allows deduction of structure-activity relationships and gives clues to the chemical aspects involved in Ganoderma bioactivity.
TypeArticle
DescriptionReview aricle
URIhttp://hdl.handle.net/1822/39811
DOI10.1016/j.phytochem.2014.10.011
ISSN0031-9422
Publisher versionhttp://dx.doi.org/10.1016/j.phytochem.2014.10.011
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CDQuim - Artigos (Papers)

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