Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/39770

TitleGoblet cell density association with tear function and ocular surface physiology
Author(s)Sapkota, Kishor
Franco, Sandra
Sampaio, Paula
Lira, Madalena
KeywordsGoblet cell density
Schirmer score
Tear break-up time
Bulbar redness
Corneal staining
Issue dateAug-2015
PublisherElsevier
JournalContact Lens and Anterior Eye
CitationSapkota, K., Franco, S., Sampaio, P., & Lira, M. (2015). Goblet cell density association with tear function and ocular surface physiology. Contact Lens & Anterior Eye, 38(4), 240-244. doi: 10.1016/j.clae.2015.01.016
Abstract(s)Purpose: To determine the relationship of goblet cell density (GCD) with tear function and ocular surface physiology. Methods: This was a cross-sectional study conducted in 35 asymptomatic subjects with mean age 23.8±3.6 years. Tear film assessment, conjunctiva and cornea examination were done in each subject. Conjunctival impression cytology was performed by applying Nitrocellulose Millipore MFTM-Membrane filter over the superior bulbar conjunctiva. The filter paper was than fixed with 96% ethanol and stained with Periodic Acid Schiff, Hematoxylin and Eosin. GCD was determined by optical microscopy. Relation between GCD and Schirmer score, tear break-up time (TBUT), bulbar redness, limbal redness and corneal staining was determined. Results: The mean GCD was 151±122 cells/mm2. GCD was found higher in eyes with higher Schirmer score but it was not significant (p = 0.75). There was a significant relationship ofGCDwith TBUT (p = 0.042). GCD was not correlated with bulbar redness (p = 0.126), and limbal redness (p = 0.054) as well as corneal staining (p = 0.079). No relationship of GCD with age and gender of the subjects (p > 0.05) was observed. Conclusion: GCD was found correlated with TBUT but no significant correlation was found with the aqueous portion of the tear, limbal as well as bulbar redness and corneal staining.
TypeArticle
URIhttp://hdl.handle.net/1822/39770
DOI10.1016/j.clae.2015.01.016
ISSN1367-0484
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CDF - OCV - Artigos/Papers (with refereeing)

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