Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/39071

TítuloAminobenzocoumarinylmehtyl esters as photoactive precursors for the release of butyric acid
Autor(es)Soares, Ana M. S.
Hungerford, Graham
Costa, Susana P. G.
Gonçalves, M. Sameiro T.
Palavras-chaveButyric acid
EditoraRoyal Society of Chemistry
RevistaNew Journal of Chemistry
CitaçãoAna M. S. Soares, Graham Hungerford, Susana P. G. Costa, M. Sameiro T. Gonçalves, N. J. Chem., 2015, 39, 7227-7233.
Resumo(s)The evaluation of the photorelease of a carboxylic acid drug, using butyric acid as a representative model, was carried out by using 7-amino-4-chloromethyl-2-oxo-2Hnaphtho[1,2-b] pyran, an aminobenzocoumarin, and its mono- and di-methylated or ethylated derivatives. This study was intended to improve the release of butyric acid from benzocoumarins by the addition of an amino group to the heterocycle by applying the knowledge of second-generation coumarinylmethyl-based photoremovable protecting groups. Photolysis studies were performed on the resultant ester cages by irradiation in a photochemical reactor at 254, 300, 350 and 419 nm, using methanol/HEPES buffer 80:20 solutions as solvent. The data obtained showed that these new fluorescent aminobenzocoumarins are superior to all the previously tested benzocoumarins with the same or different ring fusions. As well as the photolysis, the photophysics of the compounds were characterised by both steady state and time-resolved methods.
Versão da editorahttp://pubs.rsc.org/en/Content/ArticleLanding/2015/NJ/C5NJ00699F#!divAbstract
Arbitragem científicayes
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